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11 Cards in this Set
- Front
- Back
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CPK & CK Clinical Implications
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Myocardial Infarction
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What are CPK & CK
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Enzymes found in heart, skeletal muscle and brain tissue. Used to assess myocardium and muscle damage.
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CPK is divided into 3 enzymes
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MM, BB, MB
MM- Skeletal muscle BB- brain tissue MM & MB- cardiac muscle |
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Isoenzyme studies for CPK do what?
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Determine if the CPK is from the heart(MB) or muscle(MM)
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What does elevation of MB indicate?
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Most definitive indication of myocardial cell damage.
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In acute MI, what does the CK/CPK do?
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Begins to increase in 2-4 hours, usually returns to normal w/in 24-48 hours.
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Interfering factors for CPK & CK
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Exercise, salicylates, childbirth, multiple injections, athletes have higher value from increased muscle mass
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What are Troponins?
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Assay can detect MI w/ greater sensitivity and specificity.
troponin T(cTNT) & troponin I (cTNI) |
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What are normal levels of Troponins?
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Very low.
Increases substantially 4-6 hours post muscle damage, peaks at 10-24 hours and can be detected for up to a week. |
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Uses for BNP?
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B-type Natriutetic protein
Used to diagnose CHF, ventricles produce extra BNP when can't pump enough to meet body needs. Higher values = heart failure |
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What is C-reactive proteins?
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MI precurser.
Increase significant for suspected risk of MI. |
