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32 Cards in this Set
- Front
- Back
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Acute DFI causative pathogens
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Monomicrobial usually
- Gram (+) cocci: . Staph aureus . B hemolytic Streptococci (ABC+G) |
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Chronic DFI causative pathogens
(prev treated) |
-Gram (+) cocci (same as acute)
- Gram (-) rods: . proteus spp., e coli, klebsiella spp. |
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Acute DFI
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. cellulitis without open skin wound
. infected ulcers and antibiotic naive |
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Chronic DFI
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.Chronic foot ulcers or previously treated
.Macerated ulcers due to soaking |
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Chronic DFI causative pathogens
(due to soaking) |
Ps. aeruginosa (often w/ other)
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Chronic DFI causative pathogens
(long duration- ATB resistant spp.) |
-Gram + cocci:
. s. aureus (risk of MRSA) . s epidermidis . enterococci (including VRE) -Enterobacteriacae (risk of B lactamase) -Ps aeruginosa -Nonfermentative gram negative rods -Candidal spp (Fungal) |
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Chronic DFI causative pathogens
(extensive necrosis, gangrene, or malodorous) |
-Gram + cocci
. s aureus, s epidermidis, enterococci -Enterobacteriacae -Nonfermentative gram negative rods -Obligate anaerobes |
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Treatment of Cellulitis
Mild to Moderate (staph or strep) |
Dicloxacillin 250-500mg po qid
Cephalexin 250-500mg po qid Cefadroxil 500mg po bid Duration of therapy: 7-10 days |
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Treatment of Cellulitis
Mild to Moderate (staph or strep) * with B lactam allergy |
Erythromycin 250-500mg po qid
Clindamycin 150-300mg po qid Duration of therapy: 7-10 days |
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Treatment of Cellulitis
Moderate-severe (staph or strep) |
Nafcillin 1-2g IV q4H or q6H
*B lactam allergy: Cefazolin, Clindamycin Duration of therapy: 10-14 days |
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Aminopenicillins w/B lac inhibitor
Empirical Ab for Mod to serious DFI |
Ampicillin/sulbactam (Unasyn)
Amoxicillin/clavulanic acid (Augmentin) |
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Antipseudomonal PCN w/ B-lactamase inhibitors
Empirical Ab for Mod to serious DFI |
Piperacillin/tazobactam (Zosyn)
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1st generation cephalosporins
Empirical Ab for Mod to serious DFI |
Cefazolin (Ancef)
Cefadroxil (Duricef) Cephalexin (Keflex) |
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3rd generation cephalosporins
Empirical Ab for Mod to serious DFI |
Ceftizoxime (Ceftizox)
Ceftazidime (Fortaz) Ceftriaxone (Rocephin) |
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Carbapenems
Empirical Ab for Mod to serious DFI |
Imipenem/cilastatin (Primaxin)
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Fluoroquinolones
Empirical Ab for Mod to serious DFI |
Ciprofloxacin
L-levofloxacin |
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Misc
Empirical Ab for Mod to serious DFI |
Clindamycin (Cleocin)
Vancomycin |
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Empiric Therapy: DFI regimens 1
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Clindamycin 600mg IV q8H
+ Gent or tobramycin 1.5mg/kg IV q8H or Ciprofloxacin 400mg IV q8H or q12H or Ceftizoxime 1-2g IV q8H |
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Empiric Therapy: DFI regimens 2
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Piperacillin/tazobactam 4.5g IV q8H
+ Gent or tobramycin 1.5mg/kg IV q8H |
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Empiric Therapy: DFI regimens 3
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Imipenem 500mg IV q6H
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Aminopenicillins w/B lac inhibitor
Empirical Ab for Mod to serious DFI |
Ampicillin/sulbactam (Unasyn)
Amoxicillin/clavulanic acid (Augmentin) |
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Antipseudomonal PCN w/ B-lactamase inhibitors
Empirical Ab for Mod to serious DFI |
Piperacillin/tazobactam (Zosyn)
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1st generation cephalosporins
Empirical Ab for Mod to serious DFI |
Cefazolin (Ancef)
Cefadroxil (Duricef) Cephalexin (Keflex) |
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3rd generation cephalosporins
Empirical Ab for Mod to serious DFI |
Ceftizoxime (Ceftizox)
Ceftazidime (Fortaz) Ceftriaxone (Rocephin) |
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Carbapenems
Empirical Ab for Mod to serious DFI |
Imipenem/cilastatin (Primaxin)
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Fluoroquinolones
Empirical Ab for Mod to serious DFI |
Ciprofloxacin
L-levofloxacin |
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Misc
Empirical Ab for Mod to serious DFI |
Clindamycin (Cleocin)
Vancomycin |
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Empiric Therapy: DFI regimens 1
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Clindamycin 600mg IV q8H
+ Gent or tobramycin 1.5mg/kg IV q8H or Ciprofloxacin 400mg IV q8H or q12H or Ceftizoxime 1-2g IV q8H |
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Empiric Therapy: DFI regimens 2
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Piperacillin/tazobactam 4.5g IV q8H
+ Gent or tobramycin 1.5mg/kg IV q8H |
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Empiric Therapy: DFI regimens 3
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Imipenem 500mg IV q6H
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Osteomyelitis Treatment
empiric therapy for hematogenous osteomyelitis (s aureus suspected) |
Nafcillin 2gm IV q4H
or Cefazolin 2gm IV q8H or Clindamycin 600mg IV q8H Duration of therapy 6 wks w/ IV |
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Osteomyelitis Treatment
empiric therapy for contiguous osteomyelitis ass. w/ vascular insufficiency (s aureus, gram-negative bacilli and anaerobes is suspected) |
Nafcillin 2gm IV q4H
or Cefazolin 2gm IV q8H + Piperacillin/tazobactam 4.5gm IV q8H Duration of therapy 6 wks w/ IV |
