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10 Cards in this Set
- Front
- Back
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insulin
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replacement, T1DM always
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tolbutamide, tolazamide, chlorpropamide, glyburide, glimepiride, glipizide
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sulfonylureas
insulin secretagogues close beta cell K+ channels causing depolarization and insulin release |
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replaginide, nateglinide
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take before meals, closes K+ channels --> depol --> insulin release
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Metformin
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DOC for T2DM, prevents onset
increased glc uptake decreased hepatic gluconeogenesis does not produce hypoglycemia! |
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Rosiglitazone, Pioglitazone
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thiazolidinedione
PPARgamma, alters gene expression increased lipid storage, decreased TNFalpha, increased adiponectin |
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acarbose, miglitol
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alpha glucosidase inhibitor
taken with meals, slows intestinal absorption of glucose |
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pramlintide
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analog of amylin, slows GI absorption, reduces appetite, reduces glucagon secretion
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Exenatide
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GLP-1 incretin analog
increased insulin secretion, beta cell growth, decreased glucagon and appetite |
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Sitagliptin
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DPP IV inhibitor, blocks degradation of endogenous incretins
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Dapagliflozin
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inhibits SGLT2 tubular glucose transporter which reabsorbs glc in nephron (increased glucose excretion)
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