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20 Cards in this Set
- Front
- Back
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Exenatide |
GLP-1 agonist |
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Liraglutide |
GLP-1 agonist |
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Sitagliptin |
DPP-4 inhib |
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Linagliptin |
DPP-4 inhib |
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Saxagliptin |
DPP-4 inhib |
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Alogliptin |
DPP-4 inhib |
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competitive inhibitors thatare DPP-4 inhibs |
Sitagliptin and alogliptin |
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DPP-4 inhib that binds enzyme covalently |
Saxagliptin |
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First gen sulfonylureas |
Chlorpropamide, tolbutamid, tolazamide
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MOA sulfonylureas |
close K channel in b-cell so it depolarizes, insulin release via Ca influx |
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second gen sulfonylureas |
glipizide, glyburide, glimepiride |
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Meglitinides and MOA |
Nateglinide, Repaglinide- also inhibit K channel |
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has disulfram like rx |
first gen sulfonylureas |
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biguanide |
metformin |
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moa of metformin |
enhances insulin sensitivity somehow by activating AMP dependent protein kinase; decreases gluconeogenesis, increases glycolysis, glucose uptake peripherally |
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lactic acidosis |
metformin |
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thiazolidinediones |
pioglitazone, rosiglitazine |
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moa thiazolidinediones |
ligands of PPARgamma (nuclear receptor, transcription regulator); only in skel muscle, liver, fat, endothelium; increase GLUT 4 in muscle and fat; increased insulin sensitivity, decreased nf-kb |
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safe to give to pts with renal failure |
thiazolidinediones |
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Sodium Glucose Co-Transport 2 Inhibitors |
Canagliflozin, Dapaglifozin, Empaglifozin |
