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Is a group of metabolic disorders charac. by HYPERGLYCEMIA resulting from defects in insulin secretion, insulin receptor or both.
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Fasting plasma glucose conc. > or = 126mg/dL on more than one testing are diagnostic of diabetes.
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GLUCOSURIA occurs when the plasma glucose level exceeds 180mg/dL (99.9mmol/L) w/ normal renal function
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KETOSIS develops in DM from excessive synthesis of Acetyl CoA.
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The presence of ketone bodies is a frequent finding in individuals w/ severe, uncontrolled diabetes.
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In severe DM, the ratio pf B-hydroxybutyrate to acetoacetate is 6:1
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The entire process of ketosis can be reversed by INSULIN ADMINISTRATION.
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