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35 Cards in this Set
- Front
- Back
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Statin MOA
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inhibit HMG CoA reductase (HMG CoA to mevalonate)
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Statin SEs
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hepatotox, rhabdomyolisis
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Rhabdomyolisis worse if combine which 2 drugs?
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statins and fibrate
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Lipid lowering drug causing hyperglycemia?
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niacin
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Best drug for increasing HDL
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niacin
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Niacin MOA
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inhbts lipolysis and reduces VLDL/triglyc secretion
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Mecahnsim of flushing with niacin
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prostaglandin release
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Lipid lowering drug that can casue gout
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niacin
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Drug that increase tryglyceride level
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cholestyramines
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Cholestyramines MOA
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prevent bile acid reabsorption
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Two drugs that cause gallstones
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cholestyramine and fibrates
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enzyme activity decreased by fibrates causing gallastones
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7-a-hydroxylase
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Ezetimibe MOA
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prevents cholesterol reabsoprtion
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Ezetimibe SEs
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increase LFT and diarrhea
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Drug that lowers fat soluble vitamin levels and can prevent warfarin absorption
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cholestyramines
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Fibrates MOA
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upregulate LPL (increase TG clearance)
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Two drugs for high tryglyceride levels
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Fibrates and niacin
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Rapid acting insulins
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LAG (lispro, aspart, glulisine)
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Short acting insulin
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regular
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Intermediate acting insulin
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NPH
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Long acting insulins
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Glargine and Detemir
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Drug that lowers insulin sensitivity
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metfromin
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Check this before giving metformin
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creatinine levels
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Sulfonylureas MOA
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close K channel in B cells, release isnulin
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Sulfonylureas SEs
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1st gen- disulfram like 2nd gen- hypoglycemia
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Glitazones MOA
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Bind PPAR-gamma nuclear receptor and increase insulin sensitivity
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PPAR-gamma codes for?
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adiponectin and GLUT-4
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Glitazones SEs
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weight gain, edema, hepatotox, heart failure
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Acarbose/miglitol inhibit
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brush border a-glucosidases
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Drugs that lower glucose absorption
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acarbose/miglitol
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Acarbose SEs
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GI upset
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Pramlintide MOA
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amylin analog (lowers glucagon)
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GLP-1 analogs
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exenatide/liraglutide
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DPP-4 inhibitors
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Linagliptin, saxagliptin, sitagliptin
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GLP-1 analogs and DPP-4 inhibitors MOA
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lower glucagon and increase insulin release
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