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7 Cards in this Set
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- Back
- 3rd side (hint)
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Insulins
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Short: Lispro, Aspart, REgular
Middle: NPH Long: Glargine, Detemir |
T1D and T2D
hyperkalemia hyperglycemia ok with gestational diabetes neg: hypoglycemia, rarely hypersensitivity |
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Sulfonylureas
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1st gen: Tolbutamide, Chlorpropamide
2nd: Glyburide, glimpiride, glipizide |
Close K channels in beta cells so depols, insulin out
T2D only 1st- hangover-ish 2nd- hypoglycemia |
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Biguanides
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Metformin
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Maybe decreases gluconeogenesis, increases glycolysis so less serum glucose. Insulin sensitizer
1 or 2 lactic acidosis not with renal failure, so regularly check Cr |
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Glitazones
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Pioglitazone, Rosiglitazone
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Acts on PPAR, a nuclear receptor, to upreg some pros to increase insulin response
T2D alone or in combo weight gain, edema, liver and CV tox |
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a-Glucosidase Inhibitors
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Acarbose, Miglitol
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Inhib brushborder a-glucosidases so less post-pran glucose
T2D alone or in combo GI problems |
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Mimetics
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Pramlintide
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lowers glucagon
T2D hypoglycemia, nausea, diarrhea |
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GLP-1 Mimetics
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Exenatide
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increases insulin and decreases glucagon
T2D nausea, vomiting, pancreatitis |
