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41 Cards in this Set

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name long insulins
Levimir = detemir
Lantus = glargine
how to convert NPH to long insulin
NPH bid less 20% = long
Levimir
detemir
Lantus
glargine
Pramlintide dosing
2.5 - 20 u
in type 2: 10-20u ac
convert Pramlintide dose mcg to unit
mcg divided by 6 = unit
treatment algorithm type 1
insulin, diet & exercise
adjunct oral
Amylin
tx algorithm type 2
diet & exercise
Oral mono- combo- tx
Incretin mimetics
insulin
amylin
exanatide
Byetta
exanatide dose
5 mcg bid x 30 days to minimize nausea; then 10 mcg bid; decr sulfonylurea dose by 1/2 to reduce hypoglycemia
exanatide MOA
incretin; peptide hormone released by gut to normalize glucose; GLP-1 analog
exanatide how avail
5mcg, 10 mcg pens for sq
where to inj exanatide
thi, abd, upper arm
pramlintide dose
15 mcg (2.5 u) ac, increase 15 mcg q3-7 days to 60 mcg (10 u)
decrease meal-time insulin by 50%
pcol amylin
- is a beta-cell hormon co-secreted w insulin
- suppresses glucagon secretion from pancreatic alpha cells
- regulates gastric emptying
amylin analog =
pramlintide
pramlintide
Symlin
GLP-1 are inactivated by
dipeptidyl peptidase-IV (DPP-IV)
GLP-1 is a *
incretin
define incretin
peptide hormone released by gut to normalize glucose
example incretin drug
exanatide
pramlintide pt ed
take immed prior to meal of 30 gm CHO or more
Do not mix w insulin
Inject thigh or abd on opp side of insulin
pramlintide vial storage
unopened: refrig
opened: room temp ok
name rapid insulins
Novolog - aspart
Apidra - glulisine
Humalog - lispro
Novolog
rapid, aspart
Apidra
rapid, glulisine
Humalog
rapid, lispro
mixes available
Novolog 70/30
Humalog 75/25
Humalog 50/50
Exubera conversion of single to multi-dose
2 x 1 mg blister pack approx equiv to 3 mg blister pak
Exubera dose
0.05 mg/kg
Levimir
detemir; long
stability of levimir
42 days room temp
pramlintide DI
admin oral meds at least 1 hr prior because it will slow the absorption of e.g. analgesics, ab, OC
pramlintide AE
nausea, anorexia

insulin-induced severe hypoglycemia in type 1 typically occurs within 3 hrs of dosing
sitagliptin
Januvia
Januvia
sitagliptin
dose sitagliptin
100mg qd
food or no food sitagliptin
take with food or fasting
dose change sitagliptin
for renal dysfunction
sitagliptin drug interaction
none
Januvia indication
type II; alone or combo w metformin or thiaolidinedione; NOT FOR USE IN TYPE 1