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41 Cards in this Set
- Front
- Back
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name long insulins
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Levimir = detemir
Lantus = glargine |
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how to convert NPH to long insulin
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NPH bid less 20% = long
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Levimir
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detemir
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Lantus
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glargine
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Pramlintide dosing
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2.5 - 20 u
in type 2: 10-20u ac |
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convert Pramlintide dose mcg to unit
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mcg divided by 6 = unit
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treatment algorithm type 1
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insulin, diet & exercise
adjunct oral Amylin |
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tx algorithm type 2
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diet & exercise
Oral mono- combo- tx Incretin mimetics insulin amylin |
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exanatide
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Byetta
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exanatide dose
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5 mcg bid x 30 days to minimize nausea; then 10 mcg bid; decr sulfonylurea dose by 1/2 to reduce hypoglycemia
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exanatide MOA
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incretin; peptide hormone released by gut to normalize glucose; GLP-1 analog
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exanatide how avail
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5mcg, 10 mcg pens for sq
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where to inj exanatide
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thi, abd, upper arm
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pramlintide dose
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15 mcg (2.5 u) ac, increase 15 mcg q3-7 days to 60 mcg (10 u)
decrease meal-time insulin by 50% |
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pcol amylin
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- is a beta-cell hormon co-secreted w insulin
- suppresses glucagon secretion from pancreatic alpha cells - regulates gastric emptying |
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amylin analog =
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pramlintide
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pramlintide
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Symlin
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GLP-1 are inactivated by
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dipeptidyl peptidase-IV (DPP-IV)
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GLP-1 is a *
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incretin
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define incretin
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peptide hormone released by gut to normalize glucose
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example incretin drug
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exanatide
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pramlintide pt ed
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take immed prior to meal of 30 gm CHO or more
Do not mix w insulin Inject thigh or abd on opp side of insulin |
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pramlintide vial storage
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unopened: refrig
opened: room temp ok |
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name rapid insulins
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Novolog - aspart
Apidra - glulisine Humalog - lispro |
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Novolog
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rapid, aspart
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Apidra
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rapid, glulisine
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Humalog
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rapid, lispro
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mixes available
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Novolog 70/30
Humalog 75/25 Humalog 50/50 |
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Exubera conversion of single to multi-dose
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2 x 1 mg blister pack approx equiv to 3 mg blister pak
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Exubera dose
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0.05 mg/kg
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Levimir
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detemir; long
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stability of levimir
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42 days room temp
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pramlintide DI
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admin oral meds at least 1 hr prior because it will slow the absorption of e.g. analgesics, ab, OC
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pramlintide AE
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nausea, anorexia
insulin-induced severe hypoglycemia in type 1 typically occurs within 3 hrs of dosing |
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sitagliptin
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Januvia
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Januvia
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sitagliptin
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dose sitagliptin
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100mg qd
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food or no food sitagliptin
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take with food or fasting
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dose change sitagliptin
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for renal dysfunction
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sitagliptin drug interaction
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none
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Januvia indication
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type II; alone or combo w metformin or thiaolidinedione; NOT FOR USE IN TYPE 1
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