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9 Cards in this Set
- Front
- Back
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Medullary cords |
In males only Extend down into the gonadal medulla and stay there For females, any cords that develop in medulla will degenerate |
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Cortical cords |
In females only sit on the outside of the cortex oocytes must be released from outer layer of the ovary (cortex) |
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Ectopic germ cells |
Germ cells take off and go in wrong direction Extragonadal germ cell tumors Will NOT get extra gonad |
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Y chromosome influence |
Affects the medulla (man) of the undifferentiated gonad No Y-chromosome = ovaries develop (cortex) Regulates production of H-Y antigen and produces the Testis-determining factor (TDF) No Y-chromosome = No TDF = ovaries develop |
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TDF |
Testis determining factor Protein that stimulates teste differentiation Encoded by the SRY gene (sex-determining region of Y chromosome) Females = no Y-chromosome = no SRY gene = no TDF = no testes |
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TDF response |
cells of the medullary sex cords begin to differentiate into Sertoli (support) cells and anti-mullerian hormone (AMH) AMH = cells in cortical sex cords degenerate Also, primary sex cords condense and spread into the medulla |
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AMH |
Anti-mullerian hormone produced by cells of medullary sex cords in response to TDF induces degeneration of mullerian (paramesonephric) ducts Causes cells in gonadal ridge to differentiate into Leydig cells = produce T and DHT |
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Sertoli cells |
sit inside the semineferous tubules (intracordal) Make AMH Also makes meiosis inducing substances Main organizers of the testes |
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Leydig cells |
sit in the developing testes outside of the seminiferous tubules (extracordal) Produce T and DHT Induces development of the Wolffian ducts |
