Development And Structure Of Bone And Cartilage

Front 1

What are the four layers of the articular cartilage

Back 1

Superficial tangential zone
Transitional zone
Deep Zone
Calcified Zone

Front 2

Which zone of the articular cartilage contains the region of highest cellularity?

Back 2

The calcified zone, which contains the tidemark, or region of highest cellularity, just at the border of calcified and uncalcified matrix.

Front 3

Describe the cellularity of each of the four zones of the articular cartilage

Back 3

*The superficial tangential zone -- relatively acellular
*Transitional zone -- presence of spherical chondrocytes
*Deep zone -- stacking of isogenic groups
*Calcified zone -- contains the tidemark (zone of highest cellularity) at the border of calcified and uncalcifed matrix, but calcified matrix cannot support living chondrocytes

Front 4

Describe the matrix characteristics of each of the four zones of the articular cartilage

Back 4

*Superficial tangential -- collagen parallel to the surface, highest water content
*Transitional -- angulated, mesh-like arrangement of collagen fibers and highest concentration of proteoglycans
*Deep -- largest collagen fibers
*Calcified -- calcified matrix

Front 5

Which family of protein is noteable in the transduction of mechanical stimuli to chondrocytes of the articular cartilage?

Back 5

Integrins

Front 6

What characteristic gives a blue cast in an H+E stain?

Back 6

Basophilic structures stain blue/purple because they take up basic dyes