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23 Cards in this Set
- Front
- Back
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what is most common immune mediated dermatosis
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pemphigus foliaceus
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what breeds are predisposed to pemphigus foliaceus
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akita
chow chow dachsunds DSH 4-5 yrs of age |
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What are characteristics of pemphigus foliaceus
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+/- pruritis
pustular dermatitis - dry crusts, scale, alopecia, erosions, epidermal collarettes |
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Where does PF first present
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face and ears in dog and cats
-feet -clawpad -can become generalized -cat: paronchya, nipples, bilateral and symmetrical |
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What are differentials from pemphigus foliaceus
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bacterial folliculitis
dermatophytosis dermodicosis seborrheic skin diseases PE D and SLE cutaneous adverse drug rxn |
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What is auto-ab against in pemphigus foliaceus
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Desmosome autoantigen
Dogs: desmoglein 1 |
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What is pathophysiology of pemphigus foliaceus
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produce autoab against desmosomes - complement activation and inflammation
loss of epidermal cell-cell adhesion creates blisters impairment of integrity of epidermal tissues |
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What can cause pemphigus foliaceus
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Idiopathic
drug induced drug triggered paraneoplastic systemic disease chronic allergies made worse by UV light |
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what drugs have been implicated in casing PF
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penicillin
sulfa drug cephalosporins promeris certifect |
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How do you diagnose pemphigus foliaceus
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Do database to R/o other causes
histopath - acantholytic cells, subcorneal pustules, neutrophils |
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What can cause acantholysis
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pemphigus foliaceus
Dermatophytosis bacterial folliculitis |
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How do you treat pemphigus foliaceus
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Dog:
Glucocorticoid: 2-4 mg/kg daily then EOD Azathioprine: |
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what is the effect of glucocorticoids
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effect humoral and CMI
inhibit inflammatory mediators suppress autoab |
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what are SE of glucocorticoids
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PU/PD
DM increased infection risk calcinosis cutis demodicosis / dermatophytosis GI ulcer |
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What is MOA of azathioprine
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antagonize purine metabolism
interfere with RNA and DNA syntehsis cytoxic to T cells |
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what are SE of azathioprine
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myelosuppression
hepatotoxicity |
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what is PF treatment in cats
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Glucorticoids
Chlorambucil |
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what is MOA of chlorambucil
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alkylating agent
affects cross linking of DNA |
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what are SE of chlorambucil
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myelosuppression
diarrhea anorexia |
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what is long term monitoring for PF treatment
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taper med based on response and evidence of active disease
review SE routine lab work |
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What needs to be done every 2-4 weeks with PF
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recheck exam
CBC chem UA cytology |
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during PF treatment you see new lesions what should you do
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skin scrape - R/o demodicosis
Trichogram |
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what is prognosis with PF
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guarded
Cost SE may be difficult to achieve remission |
