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22 Cards in this Set
- Front
- Back
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What factors of the skin contribute to the immune defence? |
structure- e.g keratin layer cell types- immune cells and keratinocytes cytokines, chemokines genetics |
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outline the differences between the innate immune system and the adaptive immune system |
innate-first line, non specific, no memory adaptive-memory, hight specific, tolerance, self limiting |
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overreaction to antigen |
hypersenitivity |
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reaction to host tissue, chronic inflammation |
autoimmunity |
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infection not controlled tumours may form |
immunodeficiency |
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what do keratinocytes differentiate into? |
corneocytes |
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what are the important structural proteins in the keratin layer and epidermis? |
filaggrin involucrin keratin |
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what are the roles of keratinocytes with regard to immunity? |
1. sense pathogens via cell surface receptors and help mediate response 2. produce antimicrobial peptides (AMPS) that directly kill pathogens 3.produce cytokines and chemokines which recruit and regulate cells of adaptive and innate immune system |
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what type of immune cell is the langerhan cell? |
dendritic cell- thery are antigen presenting cells, characterized by the BIRBECK granule |
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what is the main skin resident immune cell? |
langerhans cell |
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are CD8+ cells found in the epidermis? |
yes-mainly in the epidermis but also the dermis |
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where are CD4+ cells found? |
dermis |
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what are the main types of T lymphocytes? |
CD8+ cells CD4+cells NK cells |
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where are T cells produced? and where are the sensitised? |
produced in bone marrow sensitised in thymus |
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how to CD4+ cells work? |
they are helper cells. help B cells to make antibodies and activate macrophages |
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how to CD8+ cells work? |
can kill infected cells directly (very important against viruses and cancer) |
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what types of dendtritic cells are found in the dermis? |
1.dermal DC- involved in antigen presenting 2. Plasmacytoid-produce IFN alpha |
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what cells do you find in the dermis? |
dendritic macrophages neutrophils mast cells |
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name some ski conditions associated with inappropriate immune response/inflammation |
psoriasis atopic dermatitis bullous pemphigoid contact dermatitis systemic sclerosis urticaria systemic lupus erythematous skin infection skin tumours |
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if there is no dry skin what can you exclude |
eczema |
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What type of hypersensitivity reaction is an allergic reaction? |
type 1- IgE mediated |
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what factors affect the skin immune response? |
ageing- change in skin structure sunlight organ transplant- immunosuppresion |
