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26 Cards in this Set
- Front
- Back
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Ectodermal Dysplasia
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Group of inherited disorders characterized by dysplasia, hypoplasia, or aplasia of skin, hair, nails, teeth, and/or sweat glands.
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Hypohidrotic Ectodermal Displasia
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Best known type of ectodermal dysplasia. Usually X-linked inheritance.
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White Sponge Nevus
(Cannon's Disease) |
Benign, inherited skin disorder characterized by a defect in keratins 4 and 13. A cytologic smear may be more useful than a biopsy.
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Hereditary Benign Intraepithelial Dyskeratosis
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Inherited disorder of keratinization
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Dyskeratosis Congenita
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Rare, X-linked recessive disease
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Xeroderma Pigmentosum
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Rare skin condition caused by a defect in DNA repair in which patients develop numerous cutaneous malignancies at an early age.
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Incontinentia Pigmenti
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X-linked donmiinant disease of the skin, eyes, hair, teeth, and central nervous system
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Darier's Disease (Keratosis Follicularis)
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Inherited condition characterized by skin, mucous membrane, and nail changes.
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Warty Dyskeratoma
(Isolated Darier's disease, focal acantholytic dyskeratosis) |
Solitary lesion histopathologically identical to Darier's diseaes, but unrelated.
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Hereditary Hemorrhagic Telangiectasia
(Osler-Weber-Rendu Syndrome) |
Hereditary disorder characterized by telangiectasias and other vascular malformations.
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Ehlers-Danlos Syndromes
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Heterogeneous group of connective tissue disorders caused by a defect in collagen production
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Tuberous Sclerosis
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Uncommon disease characterized by benign tumors and hamartomas of the CNS, skin, and other organs.
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Multiple Hamartoma Syndrome
(Cowden Syndrome) |
Inherited syndrome characterized by multiple hamartomoas of the skin, breast, thyroid, GI, GU, and brain due to a mutation in the PTEN gene
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Epidermolysis Bullosa
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Group of heterogeneous, inherited disorders characterized by blistering of the skin and mucous membranes. 3 broad categories.
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Epidermolysis Bullosa simplex
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Intraepithelial blistering caused by a defect in keratin genes. Good prognosis
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Junctional epidermolysis bullosa
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Subepithelial blistering due to a defect in components of hemidesmosomes. Bleak prognosis
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Dystrophic epidermolysis bullosa
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Subepithelial blistering due to a defect in collagen VII, dominant and recessive forms; skin lesions heal with scarring.
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Erythema Migrans
(Geographic Tongue, Benign Migratory Glossitis) |
Common, benign condition. Cause unknown (hypersensitivity to environmental factors, hormones, genetic predisposition, oral form of psoriasis?)
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Reiter's Syndrome
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Immunologically-mediated condition with a classic triad of non-gonococcal urethitis, arthritis,, and conjunctivitis. Possibly triggered by an infections agent in susceptible individuals.
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Psoriasis
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Common chronic, inflammatory skin disease characterized by increased proliferative activity of keratinocytes.
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Lichen Planus
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Relatively common, chronic mucocutaneous condition which appears to be immunologically mediated.
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Lichenoid Mucositis
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Condition which may mimic lichen planus clinically and histologically.
Caused by a variety of medications, foreign material, or cinnamon. |
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Graft vs. Host Disease
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Condition which develops mainly in recipients of allogenic bone marrow transplant when the engrafted cells perceive the host tissue as foreign.
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Lupus Erythematosus
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Most common "collagen vascular" disease in the US. Immune-mediated condition
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Systemic Sclerosis
(Scleroderma) |
Autoimmune condition resulting in dense deposition of collagen in various tissues/organs
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CREST Syndrome
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May represent a mild variant of scleroderma.
Calcinosis cutis, Raynaud's phenomenon, Esophageal strictures, Sclerodactyly, and Telangiectasia. |
