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25 Cards in this Set
- Front
- Back
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Atopic dermatitis nat history
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earlier onset (common) = more severe.
miserable if it goes into adulthood. |
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same gene is involved as...
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psoriasis.
multifactorial. |
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things that can atopy and thus a th2 response
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genetics, defects in target organs (skin, gut, bronchi), env factors, triggers.
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TH1
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favored with older siblings, rural env.
DTHypersensitivity reactions and atopics don't mount a good DTH response. |
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TH2
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favored with antibiotics, western lifestyle, urban.
more commonly in atopics. eosinophilia. |
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signs of sensitive skin
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ichythiosis (dry skin), fillagrin gene issue, palmar hyperlinearity, cracked looking skin.
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main issues with atopics
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defective cell junctions so antigens get through the immune system well.
then this messes up the adhesions even more... |
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infection common with atopics...
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staph aureus.
get a vicious cycle of colonization, scratching, spreading, reconolzation... |
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lower threshold of...
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irritation and scratching.
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intial cytokine profile
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th2 first, then th1 later.
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cell differences
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lang cells are hyperstimulated with ige on their surface.
monocytes have more phosphodiesterase so more inhibition of th1 and more upreg of th2. |
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staph antigen
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superantigen.
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why dont antihistamines work that well with atpics?
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probablky IL-31 that makes them itch...
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linear lines is a sign of...
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scratching (excoriations)
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honey crust
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sign of impetigo. often it is eczematous dermatitis that is secondarily infected.
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older localized area of eczema.
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often the nape of their neck.
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white eczema
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called pitriasis alba. need topical steroids.
this is inflammation that is not red. |
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is being hot an irritant?
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yes
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how to clear staph on skin
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dilute bleach bath.
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big things to do
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modify bathing, humidify your bedroom, moisturize your body.
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is humidity good?
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yes for atopics.
not for contact dermatitis. |
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1 derm emergency
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erythroderma.
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why are untreated short?
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so much energy goes to skin repair.
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theme of this lecture
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dont be afraid to use steroids (big guns)
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nf kappa b
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activates adhesion molecules and upregulates the immune response
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