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62 Cards in this Set

  • Front
  • Back
Which drug has a slow onset and causes hypercalcemia?
Calcipotrienne
Which drug is a vitamin D analog
Calcipotriene
Which drug has a slow onset and is a retinoid pro-drug
tazarotene
Coal tar and anthralin MOA
inhibit DNA synthesis
Coal tar is 1st or 2nd line
2nd line
what time of day should coal tar be applied?
at bedtime directly to lesions with shampoo
which drug should you only apply for 20 min
anthralin
does coal tar have an odor
yes, strong smelling
which drug has purple-brown staining
anthralin
which drug is not limited to < 20% body involvement
anthralin (good for refractory plaques)
Topical calcineurin inhibitors
pimecrolimus
tacrolimus
do topical calcineurin inhibitors have an approval for psoriasis
no, atopic dermatitis
what is an advantage of topical calcineurin inhibitors
no skin atrophy
how would you tx psoriasis of the scalp
1. keratolytics (coal tar or salicylic acid)
2. olux foam, or luxiq foam
methotrexateMOA
decreases cell proliferation
monitoring for methotrexate
CBC, SCr and LFTs, CXR
drug CI with pregnancy
calcipotriene, tazarotene, methotrexate
this systemic drug is only for severe psoriasis
acitretin
this systemic agent is used with PUVA or AVB
acretin
acretin administration instructions
take with food
systemic agent that is indicated for severe psoriasis that is not acretin
cyclosporine
cyclosporine MOA
inhibits T cell activation
SEs of cyclosporine
HTN, nephrotoxic, hyperkalemia, hepatotoxicity
you can see and increased risk of skin cancer with over 2 years of use of this of this drug
cyclosporine
SEs of PUVA
dizzy, HE, nausea
disadvantage of PUVA
time consuming and expensive
BRM shouldn't be used in:
children, elderly, live vaccines, pregnancy and lactation
TNF inhibitors
infliximab, etanercept, adlimumab
T-cell activation inhibitors
alefacept
interleukin inhibitor
ustekinumab
do this test prior to BRM
PPD (TB test)
When does rosacea affect women most
menopause
what is rosacea
inflammatory skin condition affecting central face and neck
4 theories to cause rosacea
tiny mites
sun damage
blood vessel disorder
chronic infection of H. pylori
what percent of patients develop ocular rosacea
50%
general tx measures for rosacea
avoid triggers, wear sunscreen, avoid heavy cosmetics
oral ABX tx for rosacea
macrolids, tetracyclines, oracea (40 mg doxycycline)
flagyl, dapsone, primaquine
avoid these topicals because it can worsen rosacea
topical steroids
treatment of flushing of the face for rosacea
low dose clonidine and non-selective BB
treatment of rhinophyma
surgery, ABX
what is the most common skin disorder
acne
do females or males have more severe cases
males
acne is a disease of the what unit
pilosebaceous unit (sebaceous gland and adjacent hair follicle)
acne is a multifactorial disease
genetic, hormonal, dietary and environmental factors contribute to it
4 etiologic factors of acne
1. excess sebum prod
2. sloughing of keratinocytes
3. overgrowth of propionibacterium acnes
4. subsequent inflammation and immune response
increased sebum production with what hormone
testosterone
PIMPLES
phenytoin
Isoniazid
Moisturizers
Penobarbital
Lithium
Ethionamide
Steroids
closed comedo
whitehead
mild acne has the possibility of scarring?
false
Goals of acne therapy
1. control acne lesion
2. prevent or minimize scarring
3. minimize morbidity
refer to doctor if acne:
1. scarring (papules, pustules)
2. preipitated by mds
3. if acne is persistent beyond mid-20s
Drugs used to Tx HSV
acyclovir
valacyclovir
famciclovir
doconosol (Abreva-topical)
penciclovir (topical)
Can the herpes zoster infected person be contagious if they haven't been vaccinated against it
yes
Where does herpes zoster (shingles) typically occur?
unilateral (on one side of the body)
Treatment of herpes zoster (shingles)?
oral antiviral therapy (7-10 days)
analgesics and corticoids
Treatment of postherpatic neuralgia associated with herpes zoster?
TCAs (1st line)
gabapentin, lyrica, depakote (2nd line)
at what age is the zostavax vaccine recommended?
50+ years
What skin cancer is most common?
basal cell carcinoma
What skin cancer is most deadly?
malignant melanoma
What does ABCDE stand for according to malignant melanoma?
Asymmetric
Borders are irregular
Color is uneven
Diameter is changing
Evolution of the mole
Is oral therapy vs topical therapy better for treating candida toe nail infections?
yes
How long is tinea pedis treatment typically?
1-4 weeks