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62 Cards in this Set
- Front
- Back
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Which drug has a slow onset and causes hypercalcemia?
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Calcipotrienne
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Which drug is a vitamin D analog
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Calcipotriene
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Which drug has a slow onset and is a retinoid pro-drug
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tazarotene
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Coal tar and anthralin MOA
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inhibit DNA synthesis
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Coal tar is 1st or 2nd line
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2nd line
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what time of day should coal tar be applied?
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at bedtime directly to lesions with shampoo
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which drug should you only apply for 20 min
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anthralin
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does coal tar have an odor
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yes, strong smelling
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which drug has purple-brown staining
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anthralin
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which drug is not limited to < 20% body involvement
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anthralin (good for refractory plaques)
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Topical calcineurin inhibitors
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pimecrolimus
tacrolimus |
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do topical calcineurin inhibitors have an approval for psoriasis
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no, atopic dermatitis
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what is an advantage of topical calcineurin inhibitors
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no skin atrophy
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how would you tx psoriasis of the scalp
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1. keratolytics (coal tar or salicylic acid)
2. olux foam, or luxiq foam |
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methotrexateMOA
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decreases cell proliferation
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monitoring for methotrexate
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CBC, SCr and LFTs, CXR
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drug CI with pregnancy
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calcipotriene, tazarotene, methotrexate
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this systemic drug is only for severe psoriasis
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acitretin
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this systemic agent is used with PUVA or AVB
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acretin
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acretin administration instructions
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take with food
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systemic agent that is indicated for severe psoriasis that is not acretin
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cyclosporine
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cyclosporine MOA
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inhibits T cell activation
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SEs of cyclosporine
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HTN, nephrotoxic, hyperkalemia, hepatotoxicity
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you can see and increased risk of skin cancer with over 2 years of use of this of this drug
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cyclosporine
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SEs of PUVA
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dizzy, HE, nausea
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disadvantage of PUVA
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time consuming and expensive
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BRM shouldn't be used in:
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children, elderly, live vaccines, pregnancy and lactation
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TNF inhibitors
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infliximab, etanercept, adlimumab
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T-cell activation inhibitors
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alefacept
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interleukin inhibitor
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ustekinumab
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do this test prior to BRM
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PPD (TB test)
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When does rosacea affect women most
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menopause
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what is rosacea
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inflammatory skin condition affecting central face and neck
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4 theories to cause rosacea
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tiny mites
sun damage blood vessel disorder chronic infection of H. pylori |
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what percent of patients develop ocular rosacea
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50%
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general tx measures for rosacea
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avoid triggers, wear sunscreen, avoid heavy cosmetics
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oral ABX tx for rosacea
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macrolids, tetracyclines, oracea (40 mg doxycycline)
flagyl, dapsone, primaquine |
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avoid these topicals because it can worsen rosacea
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topical steroids
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treatment of flushing of the face for rosacea
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low dose clonidine and non-selective BB
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treatment of rhinophyma
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surgery, ABX
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what is the most common skin disorder
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acne
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do females or males have more severe cases
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males
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acne is a disease of the what unit
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pilosebaceous unit (sebaceous gland and adjacent hair follicle)
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acne is a multifactorial disease
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genetic, hormonal, dietary and environmental factors contribute to it
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4 etiologic factors of acne
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1. excess sebum prod
2. sloughing of keratinocytes 3. overgrowth of propionibacterium acnes 4. subsequent inflammation and immune response |
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increased sebum production with what hormone
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testosterone
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PIMPLES
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phenytoin
Isoniazid Moisturizers Penobarbital Lithium Ethionamide Steroids |
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closed comedo
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whitehead
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mild acne has the possibility of scarring?
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false
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Goals of acne therapy
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1. control acne lesion
2. prevent or minimize scarring 3. minimize morbidity |
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refer to doctor if acne:
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1. scarring (papules, pustules)
2. preipitated by mds 3. if acne is persistent beyond mid-20s |
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Drugs used to Tx HSV
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acyclovir
valacyclovir famciclovir doconosol (Abreva-topical) penciclovir (topical) |
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Can the herpes zoster infected person be contagious if they haven't been vaccinated against it
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yes
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Where does herpes zoster (shingles) typically occur?
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unilateral (on one side of the body)
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Treatment of herpes zoster (shingles)?
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oral antiviral therapy (7-10 days)
analgesics and corticoids |
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Treatment of postherpatic neuralgia associated with herpes zoster?
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TCAs (1st line)
gabapentin, lyrica, depakote (2nd line) |
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at what age is the zostavax vaccine recommended?
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50+ years
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What skin cancer is most common?
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basal cell carcinoma
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What skin cancer is most deadly?
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malignant melanoma
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What does ABCDE stand for according to malignant melanoma?
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Asymmetric
Borders are irregular Color is uneven Diameter is changing Evolution of the mole |
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Is oral therapy vs topical therapy better for treating candida toe nail infections?
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yes
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How long is tinea pedis treatment typically?
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1-4 weeks
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