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19 Cards in this Set
- Front
- Back
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What are three drugs used in treatment of depression?
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1. Tricyclics
2. SSRI 3. MOI, monoamine oxidase inhibitors |
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What are the names of some "other" drugs?
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Zyban, Wellbutrin, Effexor, St. John's Wart
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Name five tricyclic anti-depressants.
*use namonic |
1. Vivactil
2. Elavil 3. Desipramine/Norpramin 4. Adapin 5. Tofranil |
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What is the prototype for Tricyclic antidepressants?
What kind of depression is it used for? |
Desipramine, used for MAJOR and SEVERE depression.
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How does Desipramine work?
What does it reduce? |
Blocks the uptake of NE AND serotonin into nerve terminals. Allows neurotransmitters to accumulate at synapse, leading to prolonged stimulation of receptors and eventual desensitization.
Reduces the morbid preoccupation in 50-70% of pts. |
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Antidepressants do not cause what?
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A stimulant or "high".
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What is the onset of action for Desipramine?
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About 2 weeks, but 6-12 weeks for the full effect.
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CVS SE of Despiramine?
CNS SE? |
Cardiac arrhythmias, orthostatic hypotension and reflex tachycardia.
CNS: sedation |
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SSRI's include what drugs, name three.
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Zoloft, Prozac (prototype) and Celexa.
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SE of SSRI's?
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Sexual dysfunction, insomina (different than tricyclics), anxiety, anorexia, tremors nausea and flatulence.
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Other than depression, SSRI's are also used to treat...
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OCD, panic disorder and social anxiety disorder.
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Name a common MOI used for depression and describe it's MOA.
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Nardil. Dinosaur of anti-depressants. Inhibits monoamine oxidase, enzyme that breaks down NE, DA and serotonin, so more of these accumulated at synapse.
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What is a contraindication of using MOI's?
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Pts using SSRI's and other anti-depressants should not be treated with MOIs
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What is lithium used for?
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To treat mania.
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What is important to know about using lithium?
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Has a narrow therapeutic index!! Mania pts tend to be forgetful and may forget to take meds. Can be very dangerous if they try to catch up and take several pills at once.
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SE of Lithium?
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Ataxia, tremors, confusion, convulsions.
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Lithium:
A. Treats depression B. Used w/ neurotransmitter release, re-uptake C. Narrow therapeutic index D. All of the above |
C. Narrow therapeutic index
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What is the major implication for PT when treating pts on anti-depressants?
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Sedation and drowsiness, which will affect their exercise capacity and response to rehab. Especially with tricyclics.
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Anti-depressants include...
A. Zyban B. Celexa C. Tofranil D. All of the above |
D. All of the above
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