Dennis - Endocrine

Front 1

Name 4 systemic effects of insulin

Back 1

Increased Gluc. uptake to skeletal muscle and adipose tissue

Increased formation of glycogen

Decreased breakdown of fat, Increased Aa uptake by muscle

Increased FAs uptake by adipose tissue

Front 2

Name 5 actions of Vitamin D

Back 2

Increased osteoclast and osteoblast activity in bone

With activated PTH casues increased dposition of Ca2+ in bone

Activates 1-alpha-hydroxylase in kidney activating PTH

Increases absorption of Ca2+ and PO4 in kidney

Increase Ca2+ absorption in intestine

Front 3

Name one hormone whose primary effect is to elevate serum Ca2+ conc.

Back 3

PTH

Front 4

Name the hormone that antagonises PTH raise of serum Ca2+ conc.

Back 4

Calcitonin

Front 5

Name a drug and its receptor class that will counteract the symptoms of thyrotoxicosis

Back 5

Propranolol, Beta adrenoceptors

Front 6

List 3 active hormones secreted by the thyroid gland

Back 6

Tri-idothyronine T3, Thyroxine, Calcitonin

Front 7

Name 3 hormones involved in the regulation of serum Ca2+, and indicate effect of each on Ca2+ and PO4 levels in the blood

Back 7

PTH - raises Ca2+ and lowers PO4

Activated Vit. D (calcitriol) - raises Ca2+ and PO4, Calcitonin - prevents a raise in Ca2+ and PO4

Front 8

Name 2 hormones that in excess produce tachycardia and teh receptor that it binds to

Back 8

Adrenaline - Beta1, T3 - intracellular thyroid hormone receptors that stimulate synthesis of Beta1 receptors

Front 9

What blood test would differentiate between a pituitary adenoma and adrenocortical hyperplasia?

Back 9

Plasma ACTH levels with be increased in pituitary and decreased in adrenocortical

Front 10

List 3 features of hypothyroidism you might seek in a history or examination

Back 10

Constipation, Low mood, Hoarse voice

Front 11

Suggest 3 underlying pathological mechanisms that result in hypothyroidism

Back 11

Autoimmune, Pituitary failure, Iodine deficiency, Hypothalamic failure

Front 12

List 3 blood tests that would lead to the diagnosis of hypothyroidism

Back 12

Elevation of TSH, Serum iodine, T3/T4 levels, Thyroid autoantibodies