Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/15

Click to flip

15 Cards in this Set

  • Front
  • Back
Isozymes are ?
enzymes encoded by different genes and thus different proteins but catalyze the same reaction.
Isozymes reside in .....and have different
different tissues

regulatory properties.
hexokinase II is in ________, has a _____ affinity for glucose and Similarly Hexokinase I.
- muscle
- high
Hexokinase is inhibited by its product, ......
glucose 6-P.
hexokinase IV found in liver is _____ ______ by glucose-6-P and has ___ affinity for Glucose
- not inhibited
- low
hexokinase IV also called
Glucokinase
The different hexokinases of liver and muscle reflect the different ....
roles of tissues in glucose metabolism.
Muscle breaks down glucose ..... while liver generates glucose (gluconeogenesis) ....
- for energy

- for blood glucose homeostasis.
With excess glucose in the blood, liver will ..... Therefore, hexokinase IV doesn’t need a .......for glucose as normal glucose concentration in blood is 5 mM.
take in glucose and metabolize it.

high affinity
The regulation of glucokinase is more complex.
HXIV resides in .....
the nucleus as it is bound to a regulator protein.
The binding to HXIV is much tighter when ........ is
present.
fructose 6-P
HXIV regulation by Sequestration in the nucleus
What will cause the HXIV to dissociate from the regulator protein and allow the enzyme to be active and be present in the cytosol.
Glucose competes with fructose 6-P
Regulation of Phosphofructokinase I (PFKI)

What is the committed step to glycolysis and is allosterically regulated.
PFKI
Regulation of Phosphofructokinase I (PFKI)

In PFKI, ATP is a ______ but is also __ ______ ______ as it also binds to an inhibitor site.
_ substrate
_ an allosteric inhibitor
Regulation of Phosphofructokinase I (PFKI)

Other effector molecules are ......... & ...... as an inhibitor. These all have physiological significance.
AMP, fructose 2,6-bisP as activators and citrate,