Deidre Jp Glycogen Synthesis

Front 1

Glycogen synthesis
Glycogen synthesis occurs in essentially three enzymatic steps.

Back 1

- UDP-glucose pyrophosphorylase,

- glycogen synthase and

- branching enzyme
(1,6--D glucan:1,4- -D-glucan 6--(1,4- -glucano)-transferase)

Front 2

Glycogen synthesis
Glycogen synthase
The Glycogen chain is elongated by....

Back 2

transferring a glucose unit from UDPGlc to the non-reducing end of a glycogen branch.

Front 3

Glycogen synthesis

After elongation, The enzyme .....and .....

Back 3

- cleaves a branch chain (1,4- -linkage)

- transfers the chain to form a new branch with an 1,6- -linkage.

Front 4

Glycogen synthesis
Initiation of glycogen synthesis.
Glycogen synthase requires a ..... and it cannot initiate ...

Back 4

- primer

- primer synthesis

Front 5

Glycogen synthesis
Initiation of glycogen synthesis.

Since Glycogen synthase requires a primer and it can not initiate primer synthesis. This is done by another protein molecular size, 37 kD named?

Back 5

glycogenin

Front 6

Glycogen synthesis
What is the Mechanism of glycogenin catalysis.

Back 6

- transfer of UDPglc to Tyr residue 194.

Front 7

Glycogen synthesis
Mechanism of glycogenin catalysis

- After the transfer of UDPglc to Tyr residue 194, there are 7 succesive transfers of glucose to the non-reducing end of the tyrosyl glucose to form

Back 7

a primer that glycogen synthase can now further elongate