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7 Cards in this Set

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Glycogen synthesis
Glycogen synthesis occurs in essentially three enzymatic steps.
- UDP-glucose pyrophosphorylase,

- glycogen synthase and

- branching enzyme
(1,6--D glucan:1,4- -D-glucan 6--(1,4- -glucano)-transferase)
Glycogen synthesis
Glycogen synthase
The Glycogen chain is elongated by....
transferring a glucose unit from UDPGlc to the non-reducing end of a glycogen branch.
Glycogen synthesis

After elongation, The enzyme .....and .....
- cleaves a branch chain (1,4- -linkage)

- transfers the chain to form a new branch with an 1,6- -linkage.
Glycogen synthesis
Initiation of glycogen synthesis.
Glycogen synthase requires a ..... and it cannot initiate ...
- primer

- primer synthesis
Glycogen synthesis
Initiation of glycogen synthesis.

Since Glycogen synthase requires a primer and it can not initiate primer synthesis. This is done by another protein molecular size, 37 kD named?
glycogenin
Glycogen synthesis
What is the Mechanism of glycogenin catalysis.
- transfer of UDPglc to Tyr residue 194.
Glycogen synthesis
Mechanism of glycogenin catalysis

- After the transfer of UDPglc to Tyr residue 194, there are 7 succesive transfers of glucose to the non-reducing end of the tyrosyl glucose to form
a primer that glycogen synthase can now further elongate