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19 Cards in this Set

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Glycogen Breakdown:
Phosphorylase is
Removal of a terminal glucose residue from the nonreducingend of a glycogen chain by glycogen phosphorylase.
Glycogen Breakdown:
The Phosphorylase process is
repetitive
Glycogen Breakdown:
In the Phosphorylase process the enzyme removes?
removes successive glucose residues until the fourth glucose unit from the branch point.
Glycogen Breakdown:
The product of Phosphorylase is?
-glucose-1-P.
Glycogen Breakdown:
What is an essential cofactor for phosphorylase activity.
Pyridoxal-P
Glycogen Breakdown:
In Pyridoxal-P, the phosphate group is?
an acid catalyst promoting attack by Pi on the glycosidic bond.
Glycogen Breakdown:
Pyridoxal-P is bound via a ________ to __________.
- Schiff Base

- Lys residue 679
Glycogen Breakdown:
Further degradation of glycogen occurs after ?
debranching
Glycogen Breakdown:
A debranching enzyme known as ............ degrades the remaining four glucose chain by transferring ............ and the glucose unit in alpha 1,6 linkage is hydrolyzed. Then phosphorylase can continue its action.
- oligo 1,6--> 1,4 glucantransferase

- a maltotriosyl unit to a non reducing end of another glucose branch
Glycogen Breakdown:
A debranching enzyme known as oligo 1,6--> 1,4 glucantransferase degrades the remaining four glucose chain by transferring a maltotriosyl unit to a non reducing end of another glucose branch and the glucose unit in alpha 1,6 linkage is ......
hydrolyzed. Then phosphorylase can continue its action.
Glycogen Breakdown:
Mechanism of the bifunct. debranching enzyme.

Debranching is a __ __ process.
two step
Glycogen Breakdown:
Mechanism of the bifunct. debranching enzyme.

First transferase activity on the ....
maltotriosyl group and then alpha 1,6 glucosidase activity.
Glycogen Breakdown:
Mechanism of the bifunct. debranching enzyme.
What is the product of phosphorylase activity?
Glucose1-P
Glycogen Breakdown:
Mechanism of the bifunct. debranching enzyme.

Glucose1-P, the product of phosphorylase activity is converted to ........ via phosphoglucomutase activity.
glucose 6-P
Glycogen Breakdown:
Mechanism of the bifunct. debranching enzyme.
Glucose1-P, the product of phosphorylase activity is converted to glucose 6-P via ?
phosphoglucomutase activity
Glycogen Breakdown:
Mechanism of the bifunct. debranching enzyme.

After phosphoglucomutase activity, glucose-6-P can then be metabolized either by..... or ......?
glycolysis or the pentose-P pathway.
Glycogen Breakdown:
Mechanism of P-glucomutase. The reaction begins with ...?
the enzyme phosphorylated at a Ser residue.
Glycogen Breakdown:
Mechanism of P-glucomutase.

During enzyme phosphorylated at a Ser residue, The enzyme donates the phosphoryl residue to .... to form ........
glucose-1-P to form glucose-1,6-bisP
Glycogen Breakdown:
Mechanism of P-glucomutase.

After enzyme phosphorylated at a Ser residue and glucose-1,6-bisP is formed ,The P residue at C-1 is then transferred ....
back to the enzyme reforming the phosphoenzyme and glucose 6-P.