Degenerative Diseases Of The Ns

Front 1

disease associated with caudate nucleus and frontal cortex degeneration

Back 1

Huntington's disease

Front 2

disease associated with frontal and hippocampal cortex degeneration

Back 2

Alzheimer's disease

Front 3

degeneration of the substancia nigra

Back 3

Parkinson's

Front 4

degeneration of the posterior and lateral columns

Back 4

friedreich ataxia

Front 5

degeneration of the betz cells in the motor cortex and anterior horn cells

Back 5

ALS

Front 6

symptoms associated with parkinsonism

Back 6

tremor
rigidity
akinesia/bradykinesia
postural instability - forward propulsion
decreased facial expression

Front 7

histologic findings associated with idiopathic parkinson disease

Back 7

pallor and atrophy of the substancia nigra and/or locus ceruleus
lewy bodies in the substancia nigra and/or locus ceruleus

Front 8

associated with MPTP

Back 8

acute parkinsonism syndrome

Front 9

Von Economo's disease

Back 9

post-encephalitis parkinsonism after influenza infection

Front 10

associated with involuntary choeiform movements, dementia, and psychosis

Back 10

Huntington's disease

Front 11

pathology of hunginton's disesae

Back 11

bilateral caudate atrophy

Front 12

AD disease with trinucleotide CAG repeats resulting in what

Back 12

aggregation of huntingtin protein and formation of intranuclear inclusions causing Huntington's disease

Front 13

two diseases associated with trinucleotide repeats

Back 13

Huntington's disease
Friedreich Ataxia

Front 14

manifestations of ALS

Back 14

LMN - muscle atrophy and spontaneous fasciculations
UMN - weakness and spasticity

Front 15

manifestations of Friedreich Ataxia

Back 15

cerebellar ataxia, spasticity, and sensorimotor peripheral neuropathy

Front 16

pathogenesis of friedreich ataxia

Back 16

trinucleotide repeat expansion (GAA) on chromosome 9

Front 17

caused by fibrosis of meninges that pinches off the dorsal root

Back 17

Tabes Dorsalis

Front 18

degeneration of cortical neurons in the motor cortex and ventral motor nerve root

Back 18

ALS

Front 19

subacute combined degeneration

Back 19

B12 deficiency
atrophy of the posterior and lateral column and anterior horn

Front 20

progressive deterioration of higher cognitive function with impariment of previously attained function

Back 20

dementia

Front 21

cognitive impairment associated with a person who has never attained certain milestones

Back 21

mental retardation

Front 22

cognitive impairment is temporary and not progressive

Back 22

delirium

Front 23

most common cause of dementia

Back 23

Alzheimers

Front 24

pathology seen in Alzheimers

Back 24

1. Senile plaques - extracellular A beta amyloid protein aggregation
2. Neurofibrillary tangles - intracellular inclusion with paired helical filament structure composed of tau protein
3. granulovacuolar degeneration

Front 25

progressive degeneration of Alzheimers

Back 25

initially affects the hippocampus and temporal lobe, than affects the neocortex, and eventually the deep gray matter and brain-stem

Front 26

associated with hyperphosphorylated Tau protein

Back 26

Neurofibrillary tangles

Front 27

pathogenesis of alzheimers

Back 27

missense mutation on amyloid protein gene on chromosome 21

Front 28

all patients with down's syndrome are prone to

Back 28

alzheimers dementia due to chromosome 21 trisomy

Front 29

where can amyloid aggregates be found

Back 29

brain parenchyma - senile plaques
around vessels - amyloid angiopathy

Front 30

what is associated with the degree of dementia in Alzheimers

Back 30

neurofibrillary tangle densities, not senile plaques

Front 31

associated with atrophy of the frontal and temporal lobes, no neurofibrillary tangles nor senle plaques

Back 31

pick's dementia