Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
What is the main component of the glomerular basement membrane?
|
Type IV collagen
|
|
|
What are general clinical manifestations of renal disease?
|
Decreased GFR (increased Screat and BUN)
HTN Edema Proteinuria, hematuria Uremia |
|
|
What do the degrees of proteinuria represent?
|
Marked proteinuria - glomerular lesion
Low grade proteinuria - tubular/interstitial |
|
|
What must you distinguish with hematuria?
|
Glomerular vs nonglomerular
RBC casts are crucial |
|
|
What are the 5 clinical syndromes?
|
Nephritic syndrome (acute glomerulonephritis)
Nephrotic syndrome Rapidly progressive glomerulonephritis Acute kidney injury Chronic kidney disease |
|
|
Nephritic syndrome: clinical?
|
Hematuria
Proteinuria Azotemia |
|
|
Nephritic syndrome: common lesions?
|
Inflammation and/or proliferation
Deposits: subendothelial or post-infectious |
|
|
Nephrotic syndrome: clinical?
|
Marked proteinuria
Edema Hypercoagulable Hyperlipidemia |
|
|
Nephrotic syndrome: common lesions?
|
Podocyte/GBM injury
or Non-inflammatory |
|
|
What are the two things that drive proteinuria?
|
Structural change: altered size/charge selectivity
Functional change: altered glomerular pressure |
|
|
Isolated urinary abnormalities: clinical?
|
Hematuria and/or low grade proteinuria
|
|
|
Isolated urinary abnormalities: common lesions?
|
Mesangial deposits
or Tubulointerstitial disease or Hereditary GBM abnormality |
|
|
Acute Kidney Injury: clinical?
|
Decreased GFR
Mainly: oliguria or anuria Also: fluid retention - edema, HTN Blood studies: increased BUN, creatinine Increased serum K Acidosis |
|
|
Acute Kidney Injury: common lesions?
|
Acute tubular injury
Thrombotic microangiopathy |
|
|
Rapidly progressive glomerulonephritis: define
|
A clinical syndrome of rapid, progressive decline in renal function
AND features of GN (hematuria, proteinuria) |
|
|
Rapidly progressive glomerulonephritis: morphology?
|
Crescents - manifestation of severe glomerular injury
Other - severe vascular disease or tubulo interstitial disease |
|
|
Describe the path characteristics of RPGN with crescents.
|
Capillary wall break:
parietal epithelial cell proliferation crescent shape organization glomerular scarring |
|
|
Chronic kidney disease: clinical?
|
Progressively decreased GFR
Proteinuria and/or hematuria (disease dependent) |
|
|
Chronic kidney disease: morphological
|
Glomerulosclerosis
Tubular atrophy Interstitial fibrosis Vascular sclerosis |
|
|
What are the effects of ACEI (3)?
|
Inhibits:
vasoconstriction matrix proliferation other cytokines |
