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9 Cards in this Set
- Front
- Back
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Tamoxifen: class? agonist? antagonist?
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Selective estrogen receptor modulator
Agonist: bone, endometrium liver, coagulation Antagonist: breast |
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Tamoxifen: effects
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Minimizes osteoporosis
Vaginal bleeding Decreases total cholesterol and LDL Increased risk of clots Decreases risk of breast cancer and growth of existing cancer |
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What is the other SERM, besides tamoxifen?
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Raloxifene
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Where is aromatase present?
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Ovaries
Normal breast, cancer cells Fat, liver, muscle, brain |
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Aromatase inhibitors: when is it not effective? why?
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Not effective in premenopausal women when used alone - leads to increased GnRH secretion due to feedback loops.
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Name the 3 aromatase inhibitors.
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Anastrozole
Letrozole Exemastane |
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Aromatase inhibitors: AEs
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Hot flashes
Osteopenia/osteoporosis Arthralgias/myalgias |
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What are the 3 times hormonal therapies are used, with the drugs used?
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Adjuvant (after operation or radiation)
Premenopausal - Tamoxifen Postmenopausal - AIs Metastatic Tamoxifen, AIs Prevention Tamoxifen or Raloxifene |
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Hormonal therapy in metastatic breast cancer: usage? advantage?
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Often used as first line therapy
Less toxic than traditional chemotherapy |
