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42 Cards in this Set
- Front
- Back
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What's dosing regimen?
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Schedule of dosing.
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What's median effective dose (ED50)?
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Amount that produces desired intensity of effect in 50% of the individuals tested.
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What's median toxic dose? (TD50)
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Amount that produces toxic effect in 50% of the individuals tested.
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Equation for Therapeutic Index
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TD50/ED50
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Which one is larger...loading dose or maintenance dose?
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Loading dose.
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What's prophylactic dose?
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Amount of drug to protect the patient from contracting a specific disease. e.g.) vaccines.
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What's therapeutic dose?
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amount of drug to counter a disease after exposure or contraction.
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drops in 1 mL?
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20
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1oz = mL?
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29.57mL
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5% w/v = g/mL?
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5g/100mL
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BSA is used for what types of patient?
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1. Pediatric
2. Chemotherapy. |
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What's average BSA for an adult?
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1.73m^2
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How to calculate patient's dose with BSA?
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Patient's Dose = (Patient's BSA / BSA)*(Drug Dose)
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how to calculate BSA?
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sqroot [(cm * kg) / 3600]
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How many units / mL are in a U-100 insulin?
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100 units / mL
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How should non-isotonic solution be injected?
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- Slowly and in small volume.
- Never in large volume. |
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What's molality?
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mol of solute / kg of solvent
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What's Kf constant?
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1.86 degree/mol/kg for water.
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What is E?
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NaCl Equivalent
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What is formula for NaCl equivalent?
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(mw NaCl / i NaCl ) * (i of drug / mw of drug)
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What is g/mL of an isotonic NaCl solution
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.9 g/100mL = .009 g/mL
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(g of drug * E) / .009 determine what?
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Volume of water needed to make isotonic solution.
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isotonic solution freezes at what temperature?
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-0.52 degree
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How to calculate buffer capacity?
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amount of acid or base added / change in pH
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For blood, what is the primary and secondary buffer?
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Primary: plasma
Secondary: RBC |
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T/F. You want to avoid using highly buffered solution.
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True.
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What is the unit of milliequivalent?
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mg/mmol
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What is the daily water requirement by BSA? Normal Adult? By weight?
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- 1500mL / m^2
- 2500mL - 32mL/kg |
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What's an IV push?
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rapid infusion of a medication are given into a vein
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How many drops are in a microdrip, macro drip, and a standard drip.
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‘microdrip’ (60 drops/mL)
‘macro drip’ (10 drops/mL) ‘standard drip’ (15 drops/mL). |
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What's the difference between enteral and parenteral nutrition?
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Enteral: tubes inserted into stomach/small intestine.
Parenteral: IV |
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central vs. peripheral IV line
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Central: superior vena cava; hypertonic solution
peripheral: veins of arm/hand; requires adjustment of tonicity of IV solution. |
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Standard nutrition requirements for carb, protein, and fat.
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carb: 4 kcal/g
protein: 4 kcal/g fat: 9 kcal/g |
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What's the daily water requirement based on weight?
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30mL/kg
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What's the daily water requirement based on BSA?
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1500mL/m^2
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What's the daily water requirement based on caloric requirement
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1mL/kcal
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Does BEE equation calculate protein calories?
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NO! non-protein calories
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What's normal BMI range?
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18.5-24.9
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What's daily protein requirement based on weight?
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.8g/kg
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What is a a stock solution?
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Stock solutions are concentrated solutions of the drug or excipient and are used to prepare solutions of lesser concentrations for convenience.
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1 gallon = ? mL
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3785mL
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What's the freezing point depression equation?
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deltaT = i K c
K = 1.86 Delta T = .52 C = molaLity |
