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42 Cards in this Set
- Front
- Back
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DOC
Staph A
G + UTI
Gonorrhea |
Nafcillin
Ampicillin
Cephtriaxone |
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DOC
MRSA / C Diff
VRE
Rickettsia / chlamydia |
Vancomycin
Aminoglycoside + B lactam
Tetracycline |
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DOC
Legionella / Bordatella / Borrelia / M pneumo
Anerobes
B fragilis |
Tetracycline Macrolide good from leg and bored
B lactam
Imipenim Cilastin |
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DOC
G - UTI
Nosocomial pneumonia
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Norfloxicin
Gentamicin |
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Aztreonam
good against what bac,
not good against what |
gram -
Gram + and anerobes |
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aminoglycoside
resistance
Side effect |
poor penetration in + , inactivation
membrane and mt perturbation |
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Tetracyclines adverse reaction |
GI, superinfection, photosensitivity |
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Macrolide resistance |
decreased perm (plasmid), methylase (plasmid or constitutive), alter 50s |
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Lincosamide adverse effects |
GI, superinfection, skin |
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Linezolid
only good against what bac
Adverse
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gram +, because - have efflux
GI, myelosuppression, cheese |
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Streptogrammins
good against what bac
adverse effects |
gram +
p450 inhibit, MSK pain, increase LFT |
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What can inactivate MLSb |
ERM that methylates the 50s |
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quinolones adverse effects |
GI, dysglycemia, photosensitive, GABE inhibitoin (worse with aspirin), tendon rupture, CYP inh |
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What is a 5th gen ceph that can bind PBP2a of MRSA |
cephteroline |
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efflux resistant semi synthetic TCN
Aminocytilol which is not real aminoglyc but binds loosely so is bacteriostatic |
Tigrecycline
Spectinomycin |
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NRTI
Prototypes
Adverse effects
Metabolized where |
Abacavir, Didanosine (panc), Lamivudine
Lactic acidosis (hepatomeg, steatosis)
Not in liver unlike NNRTI |
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NNRTI
Prototypes
Adverse effects |
Efavirenz (teratogen) Nevirapine (labor)
CYP induction or inhibition |
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PI
Prototypes
Adverse effects |
ritonavir, Atazanavir
CYP inhibition, insulin resistance, lipo disorder |
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Which fusion inhibitor is a CYP inhibitor |
Maraviroc |
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Ribavirin adverse effects |
hemolytic anemia |
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Which plasmodium infects reticulocytes |
Vivax / Ovale |
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trypanosoma gambeinse medications |
pentamidine and eflornithine |
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Leishmania treatment |
penostam, amphortericin B, metefosine, fluconazole |
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What is power influenced by |
sample size |
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parametric test
what distrobution
what scale
what test |
normal
interval or ratio
t or anova |
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Non parametric test
Distrobution
scale
tests |
not normal
nominal or ordinal
chi square, man-whitney, wilcoxon rank |
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What is cumulative incidence
Incidence rate |
Follow individuals to see outcome
similar but most individuals will have different periods of time which are summed in denom |
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Selection biases |
detection - exposure results in better care
diagnostic - clincician aware of exposure
Exclusion - elegibility differences in groups |
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Alarm for selection bias |
low participation or different between groups |
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Information biases in case control
cohort
other |
recall, interviewer, reporting
observation/reporting, loss to follow up
misclassification |
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alarm for information bias |
collecting data different ways from groups |
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other CYP that metabolize drugs |
2d6 and 2c |
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loading dose |
DL = Vd Css / F |
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C bar |
F Dm / Cl tau |
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Css |
infusion rate / Cls |
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Cl |
Vd 0.7 / half life |
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half life |
0.7 / lamda n |
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which phage has non random insertion site, what does it use
Only what phage can do special transduction |
temperate , att sites
temperate |
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What do complex transposons use to be cleaved during replication |
Tn encoded resolvase |
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what is kd, what is dose at this point |
effect at 1/2 max, ED50 ` |
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Categories of non pharmacological antagonism |
physiologial or chemical |
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what is dispositional tolerance
What is pharmacodynamic tolerance |
reduction in conc at receptor form ADME
reduction in drug effect without change in conc |
