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85 Cards in this Set

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What cytokine promotes B cell growth and differentiation?
4,5
What cytokine produced by Th-1 cells
2 and interferon γ
What cytokine produced by Th-2 cells
4,5,6, 10
What cytokine secreted by helper T cells and activates macrophages
Interferon γ
What cytokine is responsible for pyogens secreted by monocytes and macrophages?
1, 6, TnF α (acute phase ones)
What cytokine enhances synthesis of IgE and IgG?
4
What cytokine enhances synthesis of IgA?
5
What cytokine released by virally infected cells?
Int α and β
What cytokine is involved in growth and activation of eosinophils?
5
Inhibits macrophage activation
4, 10
What cytokine inhibits production of Th1 cells?
10
Inhibits production of Th2 cells
Interferon γ
Mediates inflammation
1, 6, tnf α
What cytokine promotes growth and differention of bone marrow stem cells?
3
Supports T cell prolifereation, differentiation, and activation
2
What type of Hypersensitivity is responsible for glomerulonephritis
3 (PSGN)
What type of Hypersensitivity is responsible for asthma
1
What type of Hypersensitivity is responsible for rheumatic fever?
2
What type of Hypersensitivity is responsible for TB
4
What type of Hypersensitivity is responsible for allergies, anaphylaxis, hay fever
1
What type of Hypersensitivity is responsible for vasculitides
3
What type of Hypersensitivity is responsible for serum sickness
3
What type of Hypersensitivity is responsible for ABO incompatibility
2
What type of Hypersensitivity is responsible for poison ivy
4
What type of Hypersensitivity is responsible for eczema?
1
What type of Hypersensitivity is responsible for contact dermatitis?
4
What type of Hypersensitivity is responsible for Goodpasture
2
What is the pathogenesis of Paroxysmal Nocturnal Hemoglobinurea?
There RBC are deficient in GP 1 anchor (which is CD 55,59 and usually protects against complement mediated destruction). RBC undergo intravascular hemolysis.
How is PNH diagnosed?
Hamm test (RBC lyse @ low ph)
What lab test is altered in PNH?
Increase urine hemosiderin due to lysis of RBC
What is hemosiderin?
Insoluble iron complex from lysed RBCs
How do you treat PNH?
Iron to replace the loss, warfarin to prevent thrombi, definitive tx is bone marrow transplant to get bone marrow stem cell line that has GP 1 anchors
What is erythroblastois fetalis
Maternal antibodies to fetal Rh factor.
When should anti RHd immunoglobin be given?
At 28 weeks, traumatic event, 3 days of delivery
What injection should a woman with erythroblastosis fetalis be given to prevent RHd antibodies.
RHD immunoglobin binds up any foreign Rhd ab from fetus
What are clinical features of a baby under Rh attack from mom?
Hemolytic Anemia, jaundice, kenicterus, fetal death, hydrops fetalis (HIJK)
What diseases is ESR helpful for ?
Polymyalgia rheumatica, temporal arteritis, disease activity in rheumatoid arthritis, osteomyletis
Young child with tetany and candidias, hyocalcemia and immunosuppresion…what cell is deficient, and what is syndrome?
Tcell, DiGeorge
Young child with recurrent lung infections and granulomatous lesions?
CGD due to NADPH oxidase deficiency. This is where phagocytes need to have oxygen radicals to kill cells. They get granulomatous lesions because they always have tons of neutrophils around in little active infections that can not be eliminated. These neutrophils are impotent.
2 yo child with multiple viral and fungal infections and hypocalcemic (DiGeorge Syndrome). Which of the 3 types of germ cells give rise to the missing structure?
Endoderm
Child with immune disorder and repeated staph abscesses. It is found that phagocytes fail to respond to chemotaxic stimuli. What syndrome does he have?
Job Syndrome
What disorder is associated with high IgE?
Job syndrome
Which complement, interleukin, and leukotriene is responsible for neutrophil chemotaxis?
C3a
IL-8
Leukotriene B4
Why do people with Job Syndrome have cold staph absecesses?
Their neutorphils are not causing inflammation
Bruton’s Agammaglobulinemia- What is the inheritance?
X-linked (boys only) XLA
Be Wise Fools Gold Heeds False Hope
Bruton’s Agammaglobulinemia- What gene is defective and what does this result in?
Tyrosine kinase gene, low levels of all classes of immunoglobins.
Bruton’s Agammaglobulinemia: When is the disease first noticed.
After 6 months (when maternal antibodies wear off)
In DiGeorge Syndrome, what embryonic structure fails to develop?
3rd and 4th pharyngeal pouch. Think “trimic” aplasias
DiGeorge: What infections are they prone to?
Viral/fungal/protozoal
What deletion is associated with DiGeorge Syndrome?
22q11
SKID: a deficiency in what enzyme?
Adenosine Deaminase
Immune deficiency with ↓ production B cells
Bruton’s
Immune deficiency with ↓ production of T cells
DiGeorge
Immune deficiency with ↓ production of B and T
SCID
Immune deficiency with ↓ activation of B Cells
Hyper IgM, Wiskott Aldrich
Immune deficiency with ↓ activation of T cells
IL-12 deficinecy
Immune deficiency with ↓ activation of macrophages
Job’s syndrome
Immune deficiency with idiopathic dysfunction of B cells
Selective immunoglobulin deficiency, ataxia telangentia, common variable immunodeficiency
Immune deficiency with idiopathic dysfunction of T cells
Chronic mucocutaneous candidiasis
Immune deficiency with phagocyte deficiency
Leukocyte Adhesion deficienc syndrome, Chediak-Higashi disease, Chronic granulomatous disease
What would you expect to see in patient with Wiskott Aldrich Syndrome?
Wisconsins are all rich so they have waiters for everything
Wiskott
Aldrich
Immunodeficiency
Thrombocytopenia
Eczema
Recurrent pyogneic infections
What are the serum abnromalaties seen in Wiskott Aldrich syndrome?
Low IgM (the W is an upside down M) High IgA (A is up )
Name 3 common agents that those with CDG are susceptible to?
Staph, Aspergillus, E coli
What test is used for CGD
Nitro Blue Tetrazolium Dye
What disease would you see the following antibodies: antimitochondrial
PBC (primary biliary cirrhosis)
What disease would you see the following antibodies: anti-tsh
Graves
What disease would you see the following antibodies: anti-centromere
CREST syndrome
What disease would you see the following antibodies: anti-basement membrane
What disease would you see the following antibodies
IgE is associated with allergies because it is bound to what to cells?
Mast cells and basophils causing them to degranulate and release histamine?
Present in large quantities on membrane of many B cells?
M, D
Largely confined to intravascular pool
IGM
Equally distributed in intravascular and extravasuclar pool
IgG
Found on all T cells except NK cells?
CD3
Used to id B cells?
CD 19, 20, 21
Found on NK cells
CD 16
Inhibits complement C9 binding
55, 59
What is the necessity of VDJ recombination?
To allow for specificity of the antigen receptor on B and T cells?
A young boy susceptible to infection is unable to undergo VDJ recombination… What is the defect?
Deficient RAG 1 or RAG 2 genes