Day 2: Immunology

Front 1

What cytokine promotes B cell growth and differentiation?

Back 1

4,5

Front 2

What cytokine produced by Th-1 cells

Back 2

2 and interferon γ

Front 3

What cytokine produced by Th-2 cells

Back 3

4,5,6, 10

Front 4

What cytokine secreted by helper T cells and activates macrophages

Back 4

Interferon γ

Front 5

What cytokine is responsible for pyogens secreted by monocytes and macrophages?

Back 5

1, 6, TnF α (acute phase ones)

Front 6

What cytokine enhances synthesis of IgE and IgG?

Back 6

4

Front 7

What cytokine enhances synthesis of IgA?

Back 7

5

Front 8

What cytokine released by virally infected cells?

Back 8

Int α and β

Front 9

What cytokine is involved in growth and activation of eosinophils?

Back 9

5

Front 10

Inhibits macrophage activation

Back 10

4, 10

Front 11

What cytokine inhibits production of Th1 cells?

Back 11

10

Front 12

Inhibits production of Th2 cells

Back 12

Interferon γ

Front 13

Mediates inflammation

Back 13

1, 6, tnf α

Front 14

What cytokine promotes growth and differention of bone marrow stem cells?

Back 14

3

Front 15

Supports T cell prolifereation, differentiation, and activation

Back 15

2

Front 17

What type of Hypersensitivity is responsible for glomerulonephritis

Back 17

3 (PSGN)

Front 18

What type of Hypersensitivity is responsible for asthma

Back 18

1

Front 19

What type of Hypersensitivity is responsible for rheumatic fever?

Back 19

2

Front 20

What type of Hypersensitivity is responsible for TB

Back 20

4

Front 21

What type of Hypersensitivity is responsible for allergies, anaphylaxis, hay fever

Back 21

1

Front 22

What type of Hypersensitivity is responsible for vasculitides

Back 22

3

Front 23

What type of Hypersensitivity is responsible for serum sickness

Back 23

3

Front 24

What type of Hypersensitivity is responsible for ABO incompatibility

Back 24

2

Front 25

What type of Hypersensitivity is responsible for poison ivy

Back 25

4

Front 26

What type of Hypersensitivity is responsible for eczema?

Back 26

1

Front 27

What type of Hypersensitivity is responsible for contact dermatitis?

Back 27

4

Front 28

What type of Hypersensitivity is responsible for Goodpasture

Back 28

2

Front 30

What is the pathogenesis of Paroxysmal Nocturnal Hemoglobinurea?

Back 30

There RBC are deficient in GP 1 anchor (which is CD 55,59 and usually protects against complement mediated destruction). RBC undergo intravascular hemolysis.

Front 31

How is PNH diagnosed?

Back 31

Hamm test (RBC lyse @ low ph)

Front 32

What lab test is altered in PNH?

Back 32

Increase urine hemosiderin due to lysis of RBC

Front 33

What is hemosiderin?

Back 33

Insoluble iron complex from lysed RBCs

Front 34

How do you treat PNH?

Back 34

Iron to replace the loss, warfarin to prevent thrombi, definitive tx is bone marrow transplant to get bone marrow stem cell line that has GP 1 anchors

Front 36

What is erythroblastois fetalis

Back 36

Maternal antibodies to fetal Rh factor.

Front 37

When should anti RHd immunoglobin be given?

Back 37

At 28 weeks, traumatic event, 3 days of delivery

Front 38

What injection should a woman with erythroblastosis fetalis be given to prevent RHd antibodies.

Back 38

RHD immunoglobin binds up any foreign Rhd ab from fetus

Front 39

What are clinical features of a baby under Rh attack from mom?

Back 39

Hemolytic Anemia, jaundice, kenicterus, fetal death, hydrops fetalis (HIJK)

Front 40

What diseases is ESR helpful for ?

Back 40

Polymyalgia rheumatica, temporal arteritis, disease activity in rheumatoid arthritis, osteomyletis

Front 41

Young child with tetany and candidias, hyocalcemia and immunosuppresion…what cell is deficient, and what is syndrome?

Back 41

Tcell, DiGeorge

Front 42

Young child with recurrent lung infections and granulomatous lesions?

Back 42

CGD due to NADPH oxidase deficiency. This is where phagocytes need to have oxygen radicals to kill cells. They get granulomatous lesions because they always have tons of neutrophils around in little active infections that can not be eliminated. These neutrophils are impotent.

Front 43

2 yo child with multiple viral and fungal infections and hypocalcemic (DiGeorge Syndrome). Which of the 3 types of germ cells give rise to the missing structure?

Back 43

Endoderm

Front 44

Child with immune disorder and repeated staph abscesses. It is found that phagocytes fail to respond to chemotaxic stimuli. What syndrome does he have?

Back 44

Job Syndrome

Front 45

What disorder is associated with high IgE?

Back 45

Job syndrome

Front 46

Which complement, interleukin, and leukotriene is responsible for neutrophil chemotaxis?

Back 46

C3a
IL-8
Leukotriene B4

Front 47

Why do people with Job Syndrome have cold staph absecesses?

Back 47

Their neutorphils are not causing inflammation

Front 48

Bruton’s Agammaglobulinemia- What is the inheritance?

Back 48

X-linked (boys only) XLA
Be Wise Fools Gold Heeds False Hope

Front 49

Bruton’s Agammaglobulinemia- What gene is defective and what does this result in?

Back 49

Tyrosine kinase gene, low levels of all classes of immunoglobins.

Front 50

Bruton’s Agammaglobulinemia: When is the disease first noticed.

Back 50

After 6 months (when maternal antibodies wear off)

Front 51

In DiGeorge Syndrome, what embryonic structure fails to develop?

Back 51

3rd and 4th pharyngeal pouch. Think “trimic” aplasias

Front 52

DiGeorge: What infections are they prone to?

Back 52

Viral/fungal/protozoal

Front 53

What deletion is associated with DiGeorge Syndrome?

Back 53

22q11

Front 54

SKID: a deficiency in what enzyme?

Back 54

Adenosine Deaminase

Front 55

Immune deficiency with ↓ production B cells

Back 55

Bruton’s

Front 56

Immune deficiency with ↓ production of T cells

Back 56

DiGeorge

Front 57

Immune deficiency with ↓ production of B and T

Back 57

SCID

Front 58

Immune deficiency with ↓ activation of B Cells

Back 58

Hyper IgM, Wiskott Aldrich

Front 59

Immune deficiency with ↓ activation of T cells

Back 59

IL-12 deficinecy

Front 60

Immune deficiency with ↓ activation of macrophages

Back 60

Job’s syndrome

Front 61

Immune deficiency with idiopathic dysfunction of B cells

Back 61

Selective immunoglobulin deficiency, ataxia telangentia, common variable immunodeficiency

Front 62

Immune deficiency with idiopathic dysfunction of T cells

Back 62

Chronic mucocutaneous candidiasis

Front 63

Immune deficiency with phagocyte deficiency

Back 63

Leukocyte Adhesion deficienc syndrome, Chediak-Higashi disease, Chronic granulomatous disease

Front 64

What would you expect to see in patient with Wiskott Aldrich Syndrome?

Back 64

Wisconsins are all rich so they have waiters for everything
Wiskott
Aldrich
Immunodeficiency
Thrombocytopenia
Eczema
Recurrent pyogneic infections

Front 65

What are the serum abnromalaties seen in Wiskott Aldrich syndrome?

Back 65

Low IgM (the W is an upside down M) High IgA (A is up )

Front 66

Name 3 common agents that those with CDG are susceptible to?

Back 66

Staph, Aspergillus, E coli

Front 67

What test is used for CGD

Back 67

Nitro Blue Tetrazolium Dye

Front 68

What disease would you see the following antibodies: antimitochondrial

Back 68

PBC (primary biliary cirrhosis)

Front 69

What disease would you see the following antibodies: anti-tsh

Back 69

Graves

Front 70

What disease would you see the following antibodies: anti-centromere

Back 70

CREST syndrome

Front 71

What disease would you see the following antibodies: anti-basement membrane

Front 72

What disease would you see the following antibodies

Front 74

IgE is associated with allergies because it is bound to what to cells?

Back 74

Mast cells and basophils causing them to degranulate and release histamine?

Front 75

Present in large quantities on membrane of many B cells?

Back 75

M, D

Front 76

Largely confined to intravascular pool

Back 76

IGM

Front 77

Equally distributed in intravascular and extravasuclar pool

Back 77

IgG

Front 79

Found on all T cells except NK cells?

Back 79

CD3

Front 80

Used to id B cells?

Back 80

CD 19, 20, 21

Front 81

Found on NK cells

Back 81

CD 16

Front 82

Inhibits complement C9 binding

Back 82

55, 59

Front 83

What is the necessity of VDJ recombination?

Back 83

To allow for specificity of the antigen receptor on B and T cells?

Front 84

A young boy susceptible to infection is unable to undergo VDJ recombination… What is the defect?

Back 84

Deficient RAG 1 or RAG 2 genes