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81 Cards in this Set
- Front
- Back
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What neoplasm's are associated with AIDS?
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Karposi's sarcoma, invasive squamous cell carcinoma, non hodgkins, CNS
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Cancer associated with hashimoto's thyroiditis?
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marginal cell lymphoma
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Reed Sternberg cells are positive for..
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CD30 and CD15
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Hodgkins lymphoma type that is predominant in women
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nodular sclerosing
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worse prognosis for hodgkins lymphoma
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Lymphocyte depleted
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Burkitts lymphoma
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t 8-14 c myc moves to heavy chain Ig
"starry sky" appearance |
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Adult presents with cutaneous lesions, caused by HTLV -1 virus
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Adult T cell lymphoma
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Mycoses fungoides/Sezary syndrome
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Adults present with cutaneous patches.nodules
Indolent CD4 |
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Mantle Cell lymphoma
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T(11;14) overexpression of cyclin of cyclin D
CD5+ |
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follicular lymphoma
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T(14;18) bcl-2 expression (inhibits apoptosis)
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most common lymphoma in US
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diffuse large b cell lymphoma
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Lymphomas associated with EBV
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Burkitt and Hodgkin lymphomas
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Leukemia equivalent of Small lymphocytic lymphoma
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CLL
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sheets of lymphocytes with interspersed macrophages describes..
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Burkitts lymphoma
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Associated with Sjogrens, Hashimoto thyroiditis, H. pylori
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Marginal Cell MALToma
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Bimodal distribution Hodgkins lymphoma or Non-Hodgkins
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Hodgkins
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Clinical presentation that might lead you to suspect a pt may have a lymphoma
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fever, weight loss, night sweats, painless lymphadenopathy
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Numerous blast (immature) cells (>20% blasts)
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Acute leukemia
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Name the leukemia
Most common in children Bone pain is common |
ALL
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Name the leukemia
PAS+ |
ALL
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Name the leukemia
Associated with Down's |
ALL and AML
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Name the leukemia
most are CD 13/33+ |
AML
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Name the leukemia
PAS- median age of onset is 50 |
AML
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If you see fat cells in BM...
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think aplastic anemia
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Multiple Myeloma labs and symptoms
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hypercalcemia
Bone pain (lytic lesions) renal insufficiency Negative UA (but on UPEP see M protein spike) |
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Smudge cells on peripheral blood smear
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SLL or CLL
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TRAP positive
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Hairy Cell leukemia
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Name the leukemia
warm and cold agglutin antibodies, most common adult leukemia,over age 50 |
CLL
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Name the leukemia
May progress to AML or ALL |
CML
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name the leukemia
Philadelphia chromosome ALWAYS presents |
CML
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AML responds to
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all-retinoic acid
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Auer rods present in..... and treatment resulting in release of these can cause
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AML
can cause DIC |
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Most common leukemia in children
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lymphoblastic
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Only AML that is CD 13 and 33 -
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M7 AML
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Risk factors for esophageal cancer
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Barrets esophagus, alcohol/achalasia, corrosive esophagitis, diverticula, esophageal web, GERD
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Enzyme deficieny in Lesch Nyhan and treament
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HGPRT
Allopurinol |
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What binds vitamin D and brings it to the liver
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alpha 1 globulin (D binding)
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what is the precursor of vitamin D3 in the skin?
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7-dehydrocholesterol
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Symptoms of Vitamin D toxicity
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hypercalcemia, hypercalciuria, loss of appetite, stupor
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Deficiency of what vitamin causes fragility in eryhtrocytes, posterior column and spinocerebellar tract demyelination
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vitamin E
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What vitamin is a cofactor for carboxylation reactions
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biotin
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Symptoms of scurvy
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swollen gums, bruising, hemarthrosis, anemia, poor wound healing
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Another name for tocaferol
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alpha tocaferol
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Vitamins that have a function similar to glutathione
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Vitamin C, A,E
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Cytokine that promotes B cell growth and differentiation
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IL-4 and IL-5
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Produced by Th1 cells (cytokines)
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IL-2, IFN-8
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Produced by Th2 cells
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IL-10, 4,5
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Secreted by helper T cells and activates macrophages
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IFN-8
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Pyogens secreted by monocytes and macrophages
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IL-1, 6 TNF alpha
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Cytokines released by virally infected cells
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INF-alpha IFN-beta
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What GI diseases are associated with Down's
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Annular pancreas, duodenal atresia, celiac dz, Hirschsprungs
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Carcinoid tumor symptoms
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Bronchospasm, flushing, diarrhea, R sided heart murmur
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Peutz Jeghers syndrome-
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autosomal dominant syndrome, nonmalignant hamartomas throughout GI tract, hyperpigmentation, increased risk of CRC
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Molecular pathogensis of CRC
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DNA mismatch repair gene mutations- sporadic and HNPCC
APC/beta catenin- APC---K-RAS----Loss of p53 |
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Colon cancer most common place
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rectosigmoid>ascending>descending
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Pain relieved with defecation, lots of pooping, constant low grade abdominal pain
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IBS
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Eczema is what type of hypersensitivity
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Type I
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alcoholic develops rash, diarrhea, altered status..what vitamin def
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Niacin, B3
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Portions of colon most commony affected by volvulus
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cecum and sigmoid
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Most common cause of acute RLQ pain
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appendicitis
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positive AMA antibodies
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primary biliary sclerosis
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high levels of ANA and ASMA, elevated IgG, fatigue and right abdominal pain
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autoimmune hepatitis
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friable mucosa from rectum to distal transverse colon
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UC
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ERCP reveals alternating strictures and dilation
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primary sclerosing cholangitis
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most common cause of gram negative sepsis
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E. coli, klebsiella 2nd most common
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Staghorn calculi caused by
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Proteus
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What drugs have hypersensitivity reactions
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Sulfonamides, amiodarone, tetracycline
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Drugs to avoid for those with a sulfa allergy
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celccoxcib, furosemide, thiazides, probenecid, TMP-SMX, sulfasalazine, sulfanoureals, acetazolamide, sumatriptain
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MOA of Nitrofurantoin
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Bacteriocidal...reduced by bacterial protein to a reative intermediate
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clinical uses for TMP-SMX
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UTIs, shigella, MRSA, AIDS (PCP)
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What causes hemolytic uremic syndrome
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EHEC O157H7
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What shigella associated with reiters syndrome
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shigella flexneri
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Food poisoning as a result of mayo sitting out
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S. aureus
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C or S shaped bacteria that cause diarrhea
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Vibrio or Campylobacter
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Diarrhea transmitted from pet feces
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Yersinia pestis
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What vitamins should vegans supplement with their diet
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B12
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banana shaped gametocyte
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plasmodium falciuparum
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most common protozoal infection in US
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giardia vs trichomonas
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Leishmania vector
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Sandfly
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Leishmania Tx
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sodium stibogluconate
visceral- amphotericin B |
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Tx for Chagas
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nifurtimox
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