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22 Cards in this Set
- Front
- Back
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abl |
Oncogene - CML - gene product is tyrosine kinase
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c-myc
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Oncogene - Burkitt's lymphoma - gene product is a transcription factor
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bcl-2
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Oncogene - Follicular and undifferentiated lymphomas - gene product is an anti-apoptotic molecule
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erb-B2
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Oncogene - breast, ovarian, gastric carcinomas
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k-ras
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Oncogene - colon, lung, pancreatic tumors - gene product is a GTP-ase
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h-ras
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Oncogene - bladder, kidney tumors - gene product is a GTP-ase
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n-ras
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Oncogene - melanomas, hematologic malignancies - gene product is a GTP-ase
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L-myc
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Oncogene - Lung tumor - gene product is a transcription factor
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N-myc
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Oncogene - neuroblastoma - gnee product is a transcription factor
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ret
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Oncogene - MEN II, III - gene product is a tyrosine kinase
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c-kit
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Oncogene - gastrointestinal stromal tumor - gene product is a cytokine receptor
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p53
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Tumor suppressor gene - assoc. with most human cancers - induces apoptosis through BAX, blocking G1--> S phase of cell cycle
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Rb
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Tumor suppressor gene - retinoblastoma, osteosarcoma - gene product blocks G1-->S phase of cell cycle
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BRCA1
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Tumor suppressor gene - Breast and ovarian CA, DNA repair protein
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BRCA2
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Tumor suppressor gene - Breast CA - DNA repair protein
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p16
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Tumor suppressor gene - melanoma
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APC
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Tumor suppressor gene - Colorectal cancer
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WT1
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Tumor suppressor gene - Wilm's Tumor
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NF1
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Tumor suppressor gene - Neurofibromatosis 1
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NF2
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Tumor suppressor gene - Neurofibromatosis 2
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DPC
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Tumor suppressor gene - Pancreatic cancer
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DCC
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Tumor suppressor gene - Colon cancer
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