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29 Cards in this Set
- Front
- Back
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Inhibits thymidylate synthase, and therefore dTMP
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5-FU
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Overdose treated with thymidine
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5-FU
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Overdose treated with leucovorin
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Methotrexate
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Uterine pathologies (choriocarcinoma, etc.), Immunosuppression (RA, psoriasis)
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Methotrexate
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Purine analog, inhibits PRPP synthetase (which normally makes purines)
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6-mercaptopurine, 6-thioguanine
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Metabolized by xanthine oxidase, thus increased toxicity with allopurinol
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6-mercaptopurine
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purine analog that can be given with allopurinol
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6-thioguanine
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Inhibits DNA polymerase, used in ALL, AML
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Cytarabine
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Intercalates in DNA, used for childhod tumors (Wilms, Ewing's sarcoma, Rhabdomyosarcoma)
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Dactinomycin D
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Free radical generation, breaks in DNA, cardiotoxic
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Doxorubicin
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Free radical generation, breaks in DNA, pulmonary fibrosis
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Bleomycin
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Treatment for testicular cancer
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Eradicate Ball Cancer (Etoposide, Bleomycin, Cisplatin)
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Inhibits topoisomerase II
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Etoposide
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Hemorrhagic cystitis prevented with Mesna, cross-links DNA
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Cyclophosphamide
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Crosses BBB, tx for brain tumors, CNS toxicity
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Nitrosurease - put nitro on your mustang (-mustine)
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Tx for CML, alkylates DNA, causes pulmonary fibrosis
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Busulfan
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5 drugs that interfere with microtubulues
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Bendazoles, Griseofulvin, Colchicine, Vinblastine, Paclitaxel
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Tx for Wilm's tumor that has neurotoxic effects - areflexia, peripheral neuritis)
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Vincristine
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Tx for Wilm's tumor that causes bone marrow suppression
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Vinblastine (Blasts bone)
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Prevents microtubule disassembly
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Paclitaxel
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4 drugs that have nephrotoxicity, ototoxicity
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Cisplatin, aminoglycosides, vancomycin, loop diuretics
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Mechanism of cisplatin?
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cross-links DNA
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Inhibits Ribonucleotide Reductase - used in sickle cell disease
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hydroxyurea
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Prednisone toxicities? (10 things!)
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Cushing-like symptoms, immunosuppression, cataracts, acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, psychosis, insomnia
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Tamoxifen - estrogen receptor antagonist where? Agonist where?
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antagonist - breast; agonist - bone, endometrium
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SERM with no increase in endometrial carcinoma
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Raloxifene
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Monoconal antibody against HER-2 (erb-B2), cardiotoxic
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Trastuzumab
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Philadelphia chromosome bcr-abl tyrosine kinase inhibitor
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Imatinib
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Monoclonal antibody against CD20
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Rituxumab
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