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22 Cards in this Set
- Front
- Back
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Aldesleukin - mechanism?
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recombinant IL-2; stimulates T cells
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Aldesleukin - use?
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Renal Cell carcinoma, metastatic melanoma
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Erythropoietin (epoeitin) - use?
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Anemia, especially in renal failure or chemotherapy
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Filgastrim - mechanism?
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granulocyte CSF
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Sargramostim - mechanism?
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granulocyte-macrophage colony stimulating factor
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Filgastrim - use?
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recovery of bone marrow
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Sargramostim - use?
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recovery of bone marrow
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alpha-interferon - use?
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Hepatitis B and C, Kaposi's sarcoma, leukemia, malignant melanoma
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beta-interferon - use?
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Multiple sclerosis
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gamma-interferon - use?
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chronic granulomatous disease
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Oprelvekin - mechanism?
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recombinant IL-11 - stimulates megakaryocytes
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Thrombopoietin - use?
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thrombocytopenia
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Interferon toxicity?
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neutropenia
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IFN-alpha, IFN-beta mechanism?
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enhanced NK cell activity
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IFN-gamma mechanism?
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activates macrophages, Th1 cells
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Muromonab-CD3 target receptor/use?
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CD3 receptor/prevent acute transplant rejection
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Daclizumab target receptor/use?
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IL-2 receptor/prevent acute rejection of renal transplant
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Infliximab target/use?
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TNF-alpha/Crohn's, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis
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Adalimumab target/use?
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TNF-alpha/Crohn's, rheumatoid arthritis, psoriatic arthritis
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Rituximab target/use?
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CD20/ B-cell non-Hodgkin's lymphoma
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Trastuzumab target/use?
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HER2/neu receptor - in HER-2 overexpressing breast CA
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Abciximab target/use?
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Glycoprotein IIB/IIIa - Prevent cardiac ischemia in unstable angina and in patients treated with percutaneous coronary intervention
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