Day 01 - Random Stuff

Front 1

Salicylate overdose - give what?

Back 1

bicarbonate - sucks the H+ off, making salicylate charged, trapping in urine

Front 2

Amphetamine overdose - give what?

Back 2

NH4CL - forces H+ onto basic amphetamine, trapping it in urine

Front 3

this drug regenerates acetylcholinesterase (after organophosphate overdose)

Back 3

pralidoxime

Front 4

Symptoms of excess parasympathetic activity?

Back 4

DUMBBELS - diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of CNS, lacrimation, sweating and salivation

Front 5

Symptoms of excess anticholinergic activity?

Back 5

Hot as a Hare, Mad as a Hatter, Dry as a bone, Red as a Beet, Blind as a Bat, bloated as a toad

Front 6

atropine contraindicated in? (6 things)

Back 6

glaucoma, BPH, infant w/ fever, ileus, dementia, delerium, elderly

Front 7

Gardner presents with shortness of breath, salivation, miosis, diarrhea - cause? Mechanism of action?

Back 7

Cause - organophosphate toxicity; Mechanism - inhibition of Acetylcholinesterase

Front 8

30 YO schitzophrenic w/ urinary retention due to neuroleptic - treat with what?

Back 8

neostigmine or bethanochol

Front 9

enzyme that converts tyrosine to L-dopa

Back 9

tyrosine hydroxylase

Front 10

enzyme that converts choline, acetyl coA to acetylcholine

Back 10

Choline Acetyltransferase

Front 11

Mechanism of Botulinum toxin?

Back 11

inhibits Ach release from presynapse

Front 12

3 things inhibiting NE reuptake?

Back 12

cocaine, TCA, amphetamine

Front 13

Mechanism of action of ephedrine?

Back 13

encourages NE release from presynapse

Front 14

Mechanism of action of amphetamine?

Back 14

encourages NE release from presynapse, inhibits NE reuptake

Front 15

Mechanism of action of tyramine?

Back 15

encourages NE release from presynapse

Front 16

tyramine contraindicated with use of _________

Back 16

MAOI

Front 17

metabolizes NE in synapse

Back 17

COMT, MAO

Front 18

G (s) Protein --> _______ --> _________ --> ___________

Back 18

activate adenylate cyclase, increased cAMP, activate protein Kinase A

Front 19

G (q) Protein --> _______________ --> both __________ and ___________

Back 19

Phospholipase C, IP3, DAG

Front 20

DAG activates what?

Back 20

Protein Kinase C activated by?

Front 21

IP3 --> _________

Back 21

Calcium

Front 22

Phase I metabolism - name and reactions

Back 22

P450, reduction, oxidation, hydrolysis

Front 23

Phase II metabolism - name and reactions

Back 23

conjugation, acetylation, glucuronidation, sulfation - makes things polar (to be excreted in kidneys)

Front 24

Inactivate P450

Back 24

PICK EGS - Protease inhibitors, Isoniazid, Cimetadine, ketoconazole, erythromyacin, grapefruit juice, sulfonamides

Front 25

Question for Phase I clinical trial?

Back 25

is it safe?

Front 26

question for Phase II clinical trial?

Back 26

does it work?

Front 27

Question for phase III clinical trial?

Back 27

does it work better?

Front 28

alpha 1 - which kind of receptor? Action?

Back 28

G(q), vascular constriction, mydriasis, sphincter contraction

Front 29

alpha 2 - which kind of receptor? Action?

Back 29

G(i), DECREASED SNS outflow,

Front 30

beta 1 - which kind of receptor? Action?

Back 30

G(s), increased HR, contractility, renin release

Front 31

beta 2 - which kind of receptor? Action?

Back 31

G(s), VASODILATION, bronchodilation, increased HR, conractility

Front 32

M1 - which kind of receptor?

Back 32

G(q)

Front 33

M2 - which kind of receptor? Action?

Back 33

G(i), decreased HR, contractility

Front 34

M3 - which kind of receptor? Action?

Back 34

G(q), increased sweat,

Front 35

D1 - which kind of receptor? Action?

Back 35

G(s), relaxes renal vascular smooth muscle

Front 36

D2 - which kind of receptor? Action?

Back 36

G(i), modulates transmitter release, especially in brain

Front 37

H1 - which kind of receptor? Action?

Back 37

G(q), nasal, bronchial mucus production, bronchoconstriction, pain

Front 38

H2 - which kind of receptor? Action?

Back 38

G(s), gastric acid secretion

Front 39

V1 - which kind of receptor? Action?

Back 39

G(q), increased vascular smooth muscle contraction

Front 40

V2 - which kind of receptor? Action?

Back 40

G(s), increased H20 permeability in kidneys

Front 41

Mechanism of open/wide angle glaucoma?

Back 41

obstruction of outflow (canal of schlemm)

Front 42

Mechanism of closed/narrow angle glaucoma?

Back 42

obstruction of flow between iris and lens

Front 43

Contraindicated in closed angle glaucoma

Back 43

epinephrine, atropine, anything causing mydriasis

Front 44

Volume of distribution equals?

Back 44

amount of drug given/[drug] in plasma

Front 45

Clearance equals?

Back 45

.7 X volume of distribution/half life

Front 46

loading dose equals?

Back 46

Css X volume of distribution

Front 47

maintenance dose equals?

Back 47

Css X CL

Front 48

5 classes of drugs used to treat Glaucoma

Back 48

prostaglandin, alpha-agonist, beta-antagonist, diuretic, cholinomimetic