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12 Cards in this Set
- Front
- Back
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Antibiotic
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substance produced by microorganism which is toxic to other forms of life
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Antimicrobial agent
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a broader term than antibiotic that includes substances synthesized by man
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antiseptic
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harsh agent that kills on contact, usually too toxic for internal administration
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Bacteriostatic
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inhibits bacterial growth but bacteria can recover if antibiotic is removed
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Bacteriostatic and bacterialcidal is a property of what?
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Both the organism and the drug
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Difference of efflux pumps in gram + and -
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gram + secrete to extracellular space, - into the space b/w membranes
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beta-lactams: A) Target. B) 3 Resistance mechanisms. C) 3 Genetic elements
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a) transpeptidase. B) altered PBPs, lactamase production, altered out membrane proteins. C) chromosomal genes, plasmids, or chromosomal?
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Aminoglycosides: A) Target. B) 2 Resistance mechanisms. C) 2 genetic elements
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A) 30S. B) inactivating enzymes and altered ribosomal proteins. C) plasmid and chromosomal
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Tetracylines target, resistance, and genetic element.
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30S, active export, plasmid-encoded
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minimal inhibitory concentration? Minimum bactericidal concentration?
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1) lowest [] to stop growth. 2) lowest [] that kills bacterium in liquid broth
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4 indications for combination of agents
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1) empirical therapy of severe infection from unknown cause. 2) Tx of polymicrobial infections. 3) enhancement of specific infections. 4) prevention of emergence of resistant infections
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5 misuses of antibiotics
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1) Tx of nonresponsive infections (viral). 2) therapy of fever of unknown origin. 3) improper dosage. 4) inappropriate reliance on chemo, abscess not drained, foreign body not removed. 5) lack of adequate bacteriological information
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