• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/67

Click to flip

67 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
Benzophenone
some UVA activity
None
Erythrodermic
red & scaly; diffuse
None
During embryogeneis; melanocytes
migrate from the neural crest to the basal layer of the epidermis and hair matrices as well as the inner ear; (specifically the cochlea/vestibujlar apparatus); uveal tract and retina of the eye and leptomeninges. The pigmented retinal epithelium is derived from the optic cup of the neural tube.
Toxic Epidermal Necrolysis:
apoptosis of keratinocytes; peeling of epidermis
Hormonal therapy:
OCP’s; Spironolactone; oral corticosteroids].
Steven Johnson Syndrome:
hemorrhagic crusting on lips; eyes; genital area; targetoid lesions
Basal Cell Carcinoma [2]
45% diagnosed w/ BCC will have another within 5 years
Melanoma deaths
(least prevalent but most deadly)
Melanoma [2]
The most prognostic determination of melanoma is Breslows Depth. (the deeper it is; the higher the death rate)
Pustular
Pustular : generalized is potentially life-threatening; or can be localized to palms & soles
The Mutation in Epidermolysis Bullosa Simplex
Basal Cell Keratins
nodular
ID the nodular type BCC: opaque; pearly with some ulceration& telangiectasia; rolled/raisedborder w/ central pit
Rosacea
1)     Clustered; confluent; deep red inflammatory papules and pustules superimposed on a background of telengectasias and general erythema; absence of comedones.
The Mutation in Lamellar
Ichthyosis is in transglutaminase-1
adnexal structure
(exocrine gland; apocrine gland; sebaceous gland) leads to “hidradenitis supprativa” (occlusion of the follicular infundibula).
Plaque
Plaque : deep red; scaly plaques; well-demarcated
Atopic dermatitis :
decreased ceramide production
Time of Day
Time of Day (2/3 between 10 and 3)
UVB
290-320nm; sunburn; skin cancer; aging; lupus; blocked by glass
None
Reflectors
Reflectors: zinc oxide; titanium oxides; Z-cote
Pemphigus vulgaris :
auto Ab’s to one of the desmosomal proteins
Basal Cell Carcinoma [2]
Non-melanoma deaths mostly what? = 2200
corporis/cruris
Ring formation w/ red; scaly border
Melanoma deaths
most deadly skin CA
MED no sunscreen
MED w/out sunscreen 120min
capitis
non-inflammatory; black dot; and kerion subtypes; ID the pic (hair loss; scaling)
vitiligo:
functional melanocytes disappear
Topical Retinoids
[Adapalene; Tretinoin; Tazarotene]
Tinea Capitis -
Hair shaft infection by dermatophyte; Trichophyton tonsurans being most common species. Children living in urban areas often get it and systemic treatment is required. Topical tx not enough.
Tx: Mohl’s
Microsurgery for large; aggressive tumors w/ ill-defined margins & perineural involvement or in hi-risk locations or young pt’s; *If Topicals don’t work on a skin lesion; biopsy it!
Humidity
Humidity : Wet stratum corneum transmits more UVB
Antibiotics
Tetracycline; Doxycycline; Minocycline; Bactrim; Trimethoprim. Erythromycin; Clindamycin; Dapsone].
Basal Cell Carcinoma [2]
- Almost exclusively in hair-bearing skin; especially face
The Mutation in Dystrophic Epidermolysis Bullosa
Collagen VII
Hemidesmosomes
function to connect basal cell keratinocytes to basement membrane.
MED
minimal erythema dose=PF=protective factor
None
Parsol 1789
Parsol 1789 : UVA
Guttate
triggered off by streptococcal pharyngitis
None
Reflection
Reflection: Snow : Sand : Water
PABA
PABA : Esters
Cornified cell envelope
a durable protein-lipid polymer that provides mechanical and chemical protection.
Topical Antimicrobials
[Clindamycin and Benzoyl Peroxide; Erythromycin and Benzoyl Peroxide; Benzoyl Peroxide].
Basal Cell Carcinoma [2]
Most common skin carcinoma in US; Metastasis rate 0.0028%
Psoriasis
2)     Well-demarcated deep pink plaques with overlying silvery micaceous scale.
Absorbers
PABA
Atmosphere
Atmospheric conditions [clouds reduce UV exposure by only 20% - you can still burn!]
Cutis Laxa
is in the elastin gene
Desmosomes
Function to connect adjacent keratinocytes.
Season
Season : Maximal June 21
Tyrosinase
is the enzyme responsible for the conversion of Tyrosine to DOPA and of DOPA to DOPAquinone in the melanin biosynthetic pathway. Mutations in this enzyme leads to clinical disease such as oculocutaneous albinism.
UVA
320-400nm; immediate darkening; PUVA; photo-allergy; drug photo-sens.; wrinkles; passes thru glass \\
None
UVC
100-290nm; blocked by ozone; highest energy causing DNA damage; germicidal
None
The Mutation in Marfan’s
fibrillin 1 gene
Basal Cell Carcinoma [2]
Nodular; Pigmented; Morpheaform; Superficial
SPF
120/20=6
This explains the importance of why certain disease of skin pigmentation also may have abnormalities in these areas.
Lamellar membranes
Forms a hydrophobic barrier.
pedis/onychomycosis
Interdigital or vesiculobullous
When is atopic dermatitis potentially life threatening?
When there is superinfection with herpes simplex; known as eczema herpeticum.
Bullous Pemphigoid
auto Abs to proteins of the hemidesmosomes.
Mexoryl
Mexoryl SX : UVA
Bad med for psoriasis
Do not give pts w/plaque type psoriasis systemic steroids : can lead to life-threatening generalized pustular psoriasis!
Basal Cell Carcinoma [2]
Lifetime risk of non-melanoma skin CA is 1/5
Latitude
14) Latitude [proximity to equator increases UV exposure; intensity & potential damage]
Topical Creams
[Azelaic acid 20% cream; Sodium sulfacetamide; Sodium sulfacetamide/sulfur combo; Salicylic acid gel; Peels: Glycolic acid; Salicylic acid; Jessner’s.
S/E of Isotretinoin [oral retinoid]:
Dry lips; nose; eyes; skin; hair loss; birth defects; depression; nasal colonization with S. aureus; arthralgias; myalgias; headache; hypertriglyceridemia; elevated LFTs; photosensitivity; avoid elective surgery.
Cinnamates
which covering has some UVB some UVA