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67 Cards in this Set
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- 3rd side (hint)
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Benzophenone
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some UVA activity
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None
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Erythrodermic
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red & scaly; diffuse
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None
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During embryogeneis; melanocytes
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migrate from the neural crest to the basal layer of the epidermis and hair matrices as well as the inner ear; (specifically the cochlea/vestibujlar apparatus); uveal tract and retina of the eye and leptomeninges. The pigmented retinal epithelium is derived from the optic cup of the neural tube.
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Toxic Epidermal Necrolysis:
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apoptosis of keratinocytes; peeling of epidermis
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Hormonal therapy:
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OCP’s; Spironolactone; oral corticosteroids].
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Steven Johnson Syndrome:
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hemorrhagic crusting on lips; eyes; genital area; targetoid lesions
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Basal Cell Carcinoma [2]
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45% diagnosed w/ BCC will have another within 5 years
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Melanoma deaths
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(least prevalent but most deadly)
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Melanoma [2]
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The most prognostic determination of melanoma is Breslows Depth. (the deeper it is; the higher the death rate)
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Pustular
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Pustular : generalized is potentially life-threatening; or can be localized to palms & soles
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The Mutation in Epidermolysis Bullosa Simplex
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Basal Cell Keratins
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nodular
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ID the nodular type BCC: opaque; pearly with some ulceration& telangiectasia; rolled/raisedborder w/ central pit
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Rosacea
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1) Clustered; confluent; deep red inflammatory papules and pustules superimposed on a background of telengectasias and general erythema; absence of comedones.
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The Mutation in Lamellar
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Ichthyosis is in transglutaminase-1
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adnexal structure
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(exocrine gland; apocrine gland; sebaceous gland) leads to “hidradenitis supprativa” (occlusion of the follicular infundibula).
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Plaque
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Plaque : deep red; scaly plaques; well-demarcated
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Atopic dermatitis :
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decreased ceramide production
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Time of Day
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Time of Day (2/3 between 10 and 3)
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UVB
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290-320nm; sunburn; skin cancer; aging; lupus; blocked by glass
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None
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Reflectors
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Reflectors: zinc oxide; titanium oxides; Z-cote
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Pemphigus vulgaris :
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auto Ab’s to one of the desmosomal proteins
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Basal Cell Carcinoma [2]
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Non-melanoma deaths mostly what? = 2200
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corporis/cruris
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Ring formation w/ red; scaly border
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Melanoma deaths
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most deadly skin CA
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MED no sunscreen
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MED w/out sunscreen 120min
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capitis
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non-inflammatory; black dot; and kerion subtypes; ID the pic (hair loss; scaling)
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vitiligo:
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functional melanocytes disappear
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Topical Retinoids
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[Adapalene; Tretinoin; Tazarotene]
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Tinea Capitis -
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Hair shaft infection by dermatophyte; Trichophyton tonsurans being most common species. Children living in urban areas often get it and systemic treatment is required. Topical tx not enough.
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Tx: Mohl’s
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Microsurgery for large; aggressive tumors w/ ill-defined margins & perineural involvement or in hi-risk locations or young pt’s; *If Topicals don’t work on a skin lesion; biopsy it!
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Humidity
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Humidity : Wet stratum corneum transmits more UVB
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Antibiotics
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Tetracycline; Doxycycline; Minocycline; Bactrim; Trimethoprim. Erythromycin; Clindamycin; Dapsone].
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Basal Cell Carcinoma [2]
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- Almost exclusively in hair-bearing skin; especially face
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The Mutation in Dystrophic Epidermolysis Bullosa
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Collagen VII
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Hemidesmosomes
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function to connect basal cell keratinocytes to basement membrane.
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MED
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minimal erythema dose=PF=protective factor
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None
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Parsol 1789
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Parsol 1789 : UVA
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Guttate
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triggered off by streptococcal pharyngitis
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None
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Reflection
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Reflection: Snow : Sand : Water
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PABA
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PABA : Esters
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Cornified cell envelope
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a durable protein-lipid polymer that provides mechanical and chemical protection.
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Topical Antimicrobials
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[Clindamycin and Benzoyl Peroxide; Erythromycin and Benzoyl Peroxide; Benzoyl Peroxide].
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Basal Cell Carcinoma [2]
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Most common skin carcinoma in US; Metastasis rate 0.0028%
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Psoriasis
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2) Well-demarcated deep pink plaques with overlying silvery micaceous scale.
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Absorbers
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PABA
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Atmosphere
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Atmospheric conditions [clouds reduce UV exposure by only 20% - you can still burn!]
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Cutis Laxa
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is in the elastin gene
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Desmosomes
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Function to connect adjacent keratinocytes.
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Season
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Season : Maximal June 21
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Tyrosinase
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is the enzyme responsible for the conversion of Tyrosine to DOPA and of DOPA to DOPAquinone in the melanin biosynthetic pathway. Mutations in this enzyme leads to clinical disease such as oculocutaneous albinism.
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UVA
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320-400nm; immediate darkening; PUVA; photo-allergy; drug photo-sens.; wrinkles; passes thru glass \\
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None
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UVC
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100-290nm; blocked by ozone; highest energy causing DNA damage; germicidal
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None
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The Mutation in Marfan’s
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fibrillin 1 gene
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Basal Cell Carcinoma [2]
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Nodular; Pigmented; Morpheaform; Superficial
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SPF
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120/20=6
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This explains the importance of why certain disease of skin pigmentation also may have abnormalities in these areas.
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Lamellar membranes
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Forms a hydrophobic barrier.
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pedis/onychomycosis
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Interdigital or vesiculobullous
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When is atopic dermatitis potentially life threatening?
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When there is superinfection with herpes simplex; known as eczema herpeticum.
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Bullous Pemphigoid
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auto Abs to proteins of the hemidesmosomes.
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Mexoryl
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Mexoryl SX : UVA
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Bad med for psoriasis
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Do not give pts w/plaque type psoriasis systemic steroids : can lead to life-threatening generalized pustular psoriasis!
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Basal Cell Carcinoma [2]
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Lifetime risk of non-melanoma skin CA is 1/5
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Latitude
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14) Latitude [proximity to equator increases UV exposure; intensity & potential damage]
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Topical Creams
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[Azelaic acid 20% cream; Sodium sulfacetamide; Sodium sulfacetamide/sulfur combo; Salicylic acid gel; Peels: Glycolic acid; Salicylic acid; Jessner’s.
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S/E of Isotretinoin [oral retinoid]:
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Dry lips; nose; eyes; skin; hair loss; birth defects; depression; nasal colonization with S. aureus; arthralgias; myalgias; headache; hypertriglyceridemia; elevated LFTs; photosensitivity; avoid elective surgery.
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Cinnamates
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which covering has some UVB some UVA
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