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7 Cards in this Set
- Front
- Back
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What develops into cytotoxic t cells? CTL
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Activated CD8 T cells develop into cytotoxic t cells
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What is the purpose of cytotoxic t cells?
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They are important for the recognition and elimination of cells infected with viruses and some tumors.
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What can't naive CD8 T cells or CTL-precursor CTL-P cells can't do ?
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They cant kill target cells
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Activation of a CTL-P into a function CTL with ______ requires ___ sequential signals
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1) Cytotoxic activity
2) Two |
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What are the 2 signals needed to activate a CTL-P
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1) TCR/CD3 complex transmits the first signal after the recognition of an antigenic peptide displayed on an MHC class I protein on an APC
2) Is a co-stimulatory signal transmitted by the interaction of CD28-B7 Also sufficient concentration of IL-2 is required to drive this differentiation |
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After the CTL-P receives both signals 1 and 2 what does it express?
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Il-2 receptors
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Il-2 produced by ___ promotes the proliferation and differentiation of activated CTL-P into effector cytotoxic T cells
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Th1
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