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18 Cards in this Set
- Front
- Back
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Cyclophosphamide |
Ankylating agent, cross linking dna, haemorrhagic cystits, myelosuppression, TCC |
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Bleomycin |
Degraded perform dna, lung fibrosis |
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Anthracyclin (doxorubicin) |
Stabilizes DNA-topoisomerase II complex inhibits DNA & RNA synthesis, cardiomyopathy |
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Methrotrexate |
Inhibit dehydrofolate reductase and thymidylate synthesis, myelosuppresion, lung fibrosis, liver fibrosis, mucositis |
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Fluorouracil (5-FU) |
Pyrimidine analogue inducing cell cycle arrest and apoptosis by blocking thymidylate synthase (works during S phase), Myelosuppression, mucositis, dermatitis |
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6-mercaptopurine |
Purine analogue that is activated by HGPRTase, decreasing purine synthesis, myelosuppresion |
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Cytarabine |
Pyrimidine antagonist. Interferes with DNA synthesis specifically at the S-phase of the cell cycle and inhibits DNA polymerase, myelosuppresion, ataxia |
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Vincristine, vinblastine |
Inhibits formation of microtubules, Vincristine: Peripheral neuropathy (reversible) , paralytic ileus Vinblastine: myelosuppression |
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Docetaxel |
Prevents microtubule depolymerisation & disassembly, decreasing free tubulin, Neutropaenia |
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Docetaxel |
Prevents microtubule depolymerisation & disassembly, decreasing free tubulin, Neutropaenia |
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Irinotecan |
Inhibits topoisomerase I which prevents relaxation of supercoiled DNA, myelosuppresion |
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Docetaxel |
Prevents microtubule depolymerisation & disassembly, decreasing free tubulin, Neutropaenia |
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Irinotecan |
Inhibits topoisomerase I which prevents relaxation of supercoiled DNA, myelosuppresion |
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Cisplatin |
Cross link dna, Ototoxicity, peripheral neuropathy, hypomagnesaemia |
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Docetaxel |
Prevents microtubule depolymerisation & disassembly, decreasing free tubulin, Neutropaenia |
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Irinotecan |
Inhibits topoisomerase I which prevents relaxation of supercoiled DNA, myelosuppresion |
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Cisplatin |
Cross link dna, Ototoxicity, peripheral neuropathy, hypomagnesaemia |
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Hydroxyurea (hydroxycarbamide) |
Inhibits ribonucleotide reductase, decreasing DNA synthesis, Myelosuppression |
