Cytokines/hla Subtypes

Front 1

Psoriasis
Ankylosing Spondylitis
Inflammatory bowel disease
Reiter's syndrome

Back 1

HLA-B27 (PAIR)

Front 2

Grave's disease
Celiac sprue

Back 2

HLA-B8

Front 3

Hemochromatosis

Back 3

HLA-A3

Front 4

MS, hay fever, SLE, Goodpasture's

Back 4

HLA-DR2

Front 5

DM type I

Back 5

HLA-DR3/DR4

Front 6

Rheumatoid arthritis

Back 6

HLA-DR4

Front 7

Pernicious anemia (B12 def)
Hashimoto's thyroiditis

Back 7

HLA-DR5

Front 8

Lyme disease arthritis

Back 8

HLA-DR4

Front 9

Steroid-responsive nephrotic syndrome

Back 9

HLA-DR7

Front 10

ANA

Back 10

SLE

Front 11

Anti-ds DNA, anti-Smith

Back 11

Specific for SLE

Front 12

Anti-histone

Back 12

Drug induced lupus.

Front 13

Anti-IgG (RF)

Back 13

Rheumatoid arthritis

Front 14

Anti-RNP

Back 14

Mixed connective tissue disease
(low titer anti-RF/anti-ssDNA also involved)

Front 15

Anti-neutrophil (C-ANCA, P-ANCA)

Back 15

Vasculitis

Wegner's C-ANCA

Front 16

Anti-centromere

Back 16

Scleroderma, limited (CREST )

[calcinosis, raynaud's, esophageal motility disorders, sclerodactyly, telangiectasia]

Front 17

Anti-Scl-70

Back 17

Scleroderma (diffuse)

Front 18

Anti-mitochondrial

Back 18

primary biliary cirrhosis.

Front 19

Anti-gliadin

Back 19

Celiac disease

Front 20

Anti-basement membrane

Back 20

Goodpasture's

Front 21

Anti-epithelial cell

Back 21

Pemphigus vulgaris

Front 22

Anti-ssA

Back 22

Sjogren's syndrome

(dry mouth, dry eyes)

Front 23

Meaning of high anti-dsDNA?

Back 23

Thought to have prognostic significance regarding development/progression of lupus nephritis.

Front 24

Anti-microsomal

Back 24

Hashimoto's thyroiditis

Front 25

Anti-Jo-1

Back 25

Polymyositis, dermatomyositis

Front 26

Secreted by Th cells, stimulates macrophages

Back 26

IFN-gamma

Front 27

Secreted by macrophages. Increases IL-2 receptor synthesis, increases B cell proliferation. Attracts and activates neutrophils, stimulates dendritic cell migration to lymph nodes.

Back 27

TNF-alpha!

Causes cachexia of chronic inflammation, cytotoxic for tumor cells.

Front 28

Secreted by B cells and macrophages. Activates NK and Th1 cells.

Back 28

IL-12

Front 29

Secreted by Th2. Stimulates Th2 while inhibiting Th1.

Back 29

IL-10

Front 30

Major chemotact factor for neutrophils?
Complement factor involved in neutrophil chemotaxis?

Back 30

IL-8, C5a.

Front 31

Stimulates production of acute phase reactants and immunoglobulins.

Back 31

IL-6

Front 32

Promotoes differentiation of B cellls, class switching of IgA, stimulates production/activation of eosinophils?

Back 32

IL-5

Front 33

Promotes growth of B cells, stimulates class switching of IgE and IgG?

Back 33

IL-4

Front 34

Supports growth, differentiation of bone marrow stem cells.
Function similar to GM-CSF.

Back 34

IL-3

Front 35

Fun mneumonic for cytokines?

Back 35

HOT T-Bone stEAk

Front 36

Stimulates growth of helper and cytotoxic T cells.

Back 36

IL-2

Front 37

Secreted by macrophages. Stimulates T cels, B cells, neutrophils, fibroblasts, and epithelial cells to grow, differentiate, or synthesize specific products. Endogenous pyrogen.

Back 37

IL-1

Front 38

CD14?

Back 38

Macrophges.
Binds LPS, required for activation.

Front 39

B7?

Back 39

B cells. Binds CD28 on T cells, required for co-stimulation.

Front 40

CD40?

Back 40

B cells. Binds CD40L (CD154) on T ells, required to activate B cells.

Front 41

MHC I

Back 41

On all cells except mature RBCs. They are little baby cells.

Front 42

Receptors for Fc and C3b?

Back 42

Macrophages.

Front 43

Opsonization

Back 43

C3b

Front 44

Inhibit viral protein synthesis?

Back 44

IFN alpha/beta.

Front 45

Deficiency leads to Neisseria bacteremia?
Deficiecny leads to hereditary angioedema?
Deficiency leads to PNH?

Back 45

C6-8.
C1 esterase inhibitor.
Decay accelerating factor (DAF, terminates complement activation).