Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/45

Click to flip

45 Cards in this Set

  • Front
  • Back
Psoriasis
Ankylosing Spondylitis
Inflammatory bowel disease
Reiter's syndrome
HLA-B27 (PAIR)
Grave's disease
Celiac sprue
HLA-B8
Hemochromatosis
HLA-A3
MS, hay fever, SLE, Goodpasture's
HLA-DR2
DM type I
HLA-DR3/DR4
Rheumatoid arthritis
HLA-DR4
Pernicious anemia (B12 def)
Hashimoto's thyroiditis
HLA-DR5
Lyme disease arthritis
HLA-DR4
Steroid-responsive nephrotic syndrome
HLA-DR7
ANA
SLE
Anti-ds DNA, anti-Smith
Specific for SLE
Anti-histone
Drug induced lupus.
Anti-IgG (RF)
Rheumatoid arthritis
Anti-RNP
Mixed connective tissue disease
(low titer anti-RF/anti-ssDNA also involved)
Anti-neutrophil (C-ANCA, P-ANCA)
Vasculitis

Wegner's C-ANCA
Anti-centromere
Scleroderma, limited (CREST )

[calcinosis, raynaud's, esophageal motility disorders, sclerodactyly, telangiectasia]
Anti-Scl-70
Scleroderma (diffuse)
Anti-mitochondrial
primary biliary cirrhosis.
Anti-gliadin
Celiac disease
Anti-basement membrane
Goodpasture's
Anti-epithelial cell
Pemphigus vulgaris
Anti-ssA
Sjogren's syndrome

(dry mouth, dry eyes)
Meaning of high anti-dsDNA?
Thought to have prognostic significance regarding development/progression of lupus nephritis.
Anti-microsomal
Hashimoto's thyroiditis
Anti-Jo-1
Polymyositis, dermatomyositis
Secreted by Th cells, stimulates macrophages
IFN-gamma
Secreted by macrophages. Increases IL-2 receptor synthesis, increases B cell proliferation. Attracts and activates neutrophils, stimulates dendritic cell migration to lymph nodes.
TNF-alpha!

Causes cachexia of chronic inflammation, cytotoxic for tumor cells.
Secreted by B cells and macrophages. Activates NK and Th1 cells.
IL-12
Secreted by Th2. Stimulates Th2 while inhibiting Th1.
IL-10
Major chemotact factor for neutrophils?
Complement factor involved in neutrophil chemotaxis?
IL-8, C5a.
Stimulates production of acute phase reactants and immunoglobulins.
IL-6
Promotoes differentiation of B cellls, class switching of IgA, stimulates production/activation of eosinophils?
IL-5
Promotes growth of B cells, stimulates class switching of IgE and IgG?
IL-4
Supports growth, differentiation of bone marrow stem cells.
Function similar to GM-CSF.
IL-3
Fun mneumonic for cytokines?
HOT T-Bone stEAk
Stimulates growth of helper and cytotoxic T cells.
IL-2
Secreted by macrophages. Stimulates T cels, B cells, neutrophils, fibroblasts, and epithelial cells to grow, differentiate, or synthesize specific products. Endogenous pyrogen.
IL-1
CD14?
Macrophges.
Binds LPS, required for activation.
B7?
B cells. Binds CD28 on T cells, required for co-stimulation.
CD40?
B cells. Binds CD40L (CD154) on T ells, required to activate B cells.
MHC I
On all cells except mature RBCs. They are little baby cells.
Receptors for Fc and C3b?
Macrophages.
Opsonization
C3b
Inhibit viral protein synthesis?
IFN alpha/beta.
Deficiency leads to Neisseria bacteremia?
Deficiecny leads to hereditary angioedema?
Deficiency leads to PNH?
C6-8.
C1 esterase inhibitor.
Decay accelerating factor (DAF, terminates complement activation).