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53 Cards in this Set

  • Front
  • Back
↑ Eosinophil Numbers
IL 3
IL 5
Th1 release
IFN γ
Th2 Release
IL 4
(+ IL 5 + IL 13)
Th17 Release
IL - 17
Prostaglandins are made as result of
Cyclooxygenase Pathway
Prostaglandins Cause
↓ Platelet Aggregation
↑ Vasodilation
Leukotrienes are made as a result of
(Leukocytes)
Lipoxygenase Pathway
Leukotrienes Cause
Chemotaxis of Neutrophils
Vasoconstriction
↑ Bronchospasm
↑ Vascular Permeability
Serotonins are made as a result of
Platelets
Serotonin Causes
Arteriolar Dilatation
↑ Vascular Permeability
Histamine is made by
Mast Cells
Basophils
Platelets
Histamine Causes
Arteriolar Dilatation
↑ Vascular Permeability
PAF is made by
Mast Cells
Eosinophils
Lysozyme Is Made By
Macrophages
Neutrophils
Lysozyme Causes
Lysis of Bacterial Cell Wall
NO is made by
Macrophages
Endothelial Cells (from TNF and IFNγ)
NO causes
Vasodilatation
Directly Toxic
IL- 6 is released by
Macrophages
TNF is released by
Macrophages
IL-1 is released by
Macrophages
TNF/IL-6/IL-1 Result in
Acute Phase Response
(Activates EC's
Fever
NO Synthesis)
Lactoferrin/Transferrin are made by
Macrophages
Lactoferrin/Transferrin cause
Binding of iron to starve pathogen
Hagemen Factor is made by
Liver (found in plasma)
Complement is made by
Liver (found in plasma)
Bradykinin is made by
Liver (found in plasma)
Coagulation/Fibrinolytic Pathways is made by
Liver (found in plasma)
Bradykinin Causes
Pain
Vasodilation
↑ Permeability
Hagemen Factor Causes
Kinin
Clotting
Fibrinolytic
Complement Cascade
Complement Causes
MAC (Membrane Attack Complexes)
Chemotactic
Degranulation Factors
Coagulation/Fibrinolytic Pathway causes
Coagulation
Thrombosis
Function of CD59
Prevents MAC Forming on Self Cells
CD 31 Used
Diapedesis
IL-8 used as
Chemoattractant
Diapedesis of Cells uses chemoattractants:
IL 8
C5a
For Tight Binding in Cell Migration
LFA-1 on Neutrophil
ICAM-1 on Activated Endothelial Cells
IL 2 Causes
↑ Th1 + Th2
IL 15 Causes
↑Th1 and Memory Cells
IL 12 Causes
T Cell → Th1 Cell
Opsonins in Complement
C3b
iC3b
Chemotactics in Complement
C4a
C3a
C5a
Immune response stimulating fragments in Complement
C3d (key for transition to secondary response)
Regulatory proteins on self cell membrane for complement
CD59
CD35
Fibroblasts activate acute phase response with:
TNF α
il-1β
il 8
il 6
Platelets and mast cells activate APR with:
TNF α
il-1β
Infection activates APR with
LPS
Muranic Acid
dsRNA
glycans
Cortisol will act to increase
IL-1 (will eventually decrease it)
IL-6
IL 4 Acts to
↑Th2
↓ TNF
↓ il 1
↓ il 8
IL 10 Acts to
↑IL-1Ra (will mop up IL1)
IL 6 Acts to
B Cells → Plasma Cells
Stem Cell Differentiation
↑ growth factors
↑ haematopoiesis
↑ acute phase response
CXCL 12 Receptor is
CXCR4 on haemopoietic progenitors cells.
CXCL 12 is used to
Recruit haemopoietic progenitors cells to Bone Marrow
B Cells express what to activate Th cells
MHC Class 2
CD 80
CD 86