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43 Cards in this Set
- Front
- Back
- 3rd side (hint)
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endogenous pyrogen, and causes acute inflamm and lethargy
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IL-1
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activates endothelium to express adhesion mol
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IL-1
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what along with IL-1 is an endog pyrogen
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IL-6
made by what cell? |
Th2 and macroph
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who stim acute phase proteins?
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IL-6
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major chemotactic factor for neutrophils
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IL-8 "clean up on aisle 8"
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what two jobs does Il-12 have?
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different T into Th1
activate NK |
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cytokines secreated by macroph?
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IL-1
IL-6 IL-8 Il-12 TNF-alpha |
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mediates septic shock
leukocyte recruitment vascular leak |
TNF-alpha
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cytokine secreted by all Tcells
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IL-3
which is CD is also on all Tcells? |
CD3
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supports growth, differentiation of BM.
acts like GM-CSF |
IL-3
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stimulates growth of helper and cytotox cells?
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IL-2
made by? |
Th1 cells
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activates macroph and Th1 cells?
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interferon-gamma
what does it suppress? |
Th2
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antiviral and anti-tumor properties?
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interferon-gamma
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induces diff into Th2
promotes growth of Bcells |
IL-4
enhances what? |
class switching (igE>igG)
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cytokines made by TH2
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IL-4, Il-5, Il-6, Il-10
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promotes bcell differ
enhances class switching to igA |
IL-5
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stim growth and diff or eosinophils
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IL-5
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modulates inflamm resp (anti-inflamm)
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Il-10
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inhibits Th1
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IL-10
activates what? |
Th2
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cytokines secreted by Treg cells?
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IL-10
TGF-Beta both are what? |
anti-inflamm
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suppress Th2
suppress Th1 |
Interforon-gamma
IL-10 |
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what function do inf serve?
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put uninfected cells in an anti-viral mode
how? |
induce production of a ribonuclease that inhibits viral protein synth by degrading viral mRNA and not host mRNA
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inf-alpha and beta do what?
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inhibit viral protein synth
activate NK |
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inf-gamma does what?
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increases MHC1 and 2 expression on APC
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all Tcells have what cell surface proteins?
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CD3-TCR
CD28-B7 |
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CD21
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receptor for EBV
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CD40
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Bcell
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CD21
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Bcell
what mhc do bcells have? |
2
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B7
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Bcell
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CD15 & CD30
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reed-sternberg cells
dont have which CD? |
45
20 |
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CD14 and CD40
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macroph
can also bind to? |
Fc
C3b receptor to enhance phago |
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CD16
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NK
binds what? |
Fc of IgG
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CD56
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NK
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Tcells need Il-2 as a co-stim signal or else?
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anergy
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how do endotoxins/LPS work?
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directly stim macrophages by binding to...
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CD14
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relapsing fever think...
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borrelia
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what makes n. men hard to kill?
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pilus
and salmonella? |
flaggellar variants
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DNA and RNA do which of
rearrangement? reassortment |
dna-rearrange
rna-reassort (segments) reassort leads to |
major shift of a segmented RNA virus
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types of active immunity?
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vaccines
nat infection toxoid is it fast or slow? |
slow but long-lasting
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which infections require a passive booster of....
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tetanus, botulinum, rabies, HBV
booster of preformed Ab, why? |
preformed Ab work FAST
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live vaccine induce:
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humoral and cellular
whereas killed induce.. |
humoral
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what does ESR measure?
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acute phase reactants?
what mediates the production of APR? |
IL-6 from macroph
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a type of Acute phase reactant?
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fibrinogen
what does it cause? |
RBC aggregation
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