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20 Cards in this Set
- Front
- Back
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IL-1
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Secreted by macrophages
Causes acute inflammation Induces chemokine production to recruit leukocytes; activates endothelium to express adhesion molecules. An endogenous pyrogen. |
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Il-2
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Secreted by Th cells. Stimulates growth of helper and cytotoxic T cells.
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IL-3
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Secreted by activated T cells. Supports the growth and differentiation of bone marrow stem cells. Has function similar to GM-CSF.
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IL-4
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Secreted by Th2 cells.
Promotes growth of B cells. Enhances class switching to IgE and IgG. |
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IL-5
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Secreted by Th2. Promotes differentiation of B cells. Enhances the class switching of IgA. Stimulates production and activation of eosinophils.
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IL-6
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Secreted by Th cells and macrophages. Stimulates production of acute phase reactants and immunoglobulins.
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IL-8
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Secreted by macrophages. Major chemotactic factor for neutrophils.
"Clean up aisle 8": Neutrophils are recruited by IL-8 to clear infections. |
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IL-10
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Secreted by regulatory cells. INHIBITS actions of activated T cells.
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IL-12
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Secreted by B cells and macropahges. Activates NK and TH1 cells.
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Gamma-Interferon
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Secreted by Th1 cells. Stimulates Macrophages.
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TNF
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Secreted by Macrophages
Mediates septic shock. Causes leukocyte recruitment, vascular leak. |
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IL-2
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stimulates T cells
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IL-3
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stimulates bone marrow
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IL-4
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stimulates IgE production
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IL-5
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stimulates IgA production
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Cell surface proteins of Helper T cells
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CD4, TCR, CD3, CD28, CD40L
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Cell surface proteins of Cytotoxic T cells
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CD8, TCR, CD3
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Cell surface proteins of B cells
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IgM, B7, CD19, CD20, CD21, CD40, MHC II
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Cell surface proteins of Macrophages
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MHC II, B7, CD 40, CD 14, Receptors for Fc and C3b
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Cells surface cells of NK cells
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receptors for MHC I, CD 16, CD 56
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