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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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IL-1
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Pyrogen
Endothelium to express adhesion molecules Chemokine secretion to recruit leukocytes |
Secreted by macrophages
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IL-6
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Pyrogen
Production of acute-phase proteins |
Secreted by macrophages & Th cells
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IL-8
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Neutrophil chemotaxis
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Secreted by macrophages
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IL-12
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Differentiation of T cells --> Th1
Activates NK cells |
Secreted by macrophages & B cells
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TNFa
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Septic shock
Activates endothelium Leukocyte recruitment Vascular leak |
Secreted by macrophages
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IL-3
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Growth & differentiation of bone marrow stem cells (like GM-CSF)
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Secreted by Tcells
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IL-2
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Stim growth of Th & Tc cells
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Secreted by Th1 cells
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IFN gamma
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Activates macrophages & Th1 cells
Suppresses Th2 cells Antiviral & antitumor properties |
Secreted by Th1 cells
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IL-4
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Differention of T cells --> Th2
Growth of B cells Class switching to IgE & IgG |
Secreted by Th2 cells
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IL-5
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Differentiation of B cells
Class switching to IgA Growth & diff of eosinophils |
Secreted by Th2 cells
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IL-10
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Modulates inflam response
Inhibits actions of activated T cells & Th1 cells Activates Th2 |
Secreted by Th2 cells & T regulatory cells
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TNFb
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Inhibits inflammation
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IFN a & b
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Inhibit viral protein synthesis
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IFN gamma
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Increase MHC I & II expression & Ag presenting in all cells
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