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11 Cards in this Set
- Front
- Back
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IL-1
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Endogenous pyrogen-->fever, acute inflammation.
Activates endothelium to express adhesion molecules induces chemokine secretion to recruit leukocytes Secreted by macrophages |
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IL-6
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Endogenous pyrogen
Causes fever and stimulates production of acute phase proteins Secreted by Th cells and macrophages |
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IL-8
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Major chemotactic factor for neutrophils
Secreted by macrophages "Clean up on aisle 8" |
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IL-12
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Induces differentiation of T cells into Th1 cells.
Activates NK cells Secreted by macrophages and B cells |
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TNF-alpha
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Mediates septic shock
Activates endothelium Causes leukocyte recruitment Causes vascular leak Secreted by macrophages |
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IL-3
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Supports growth and differentiation of bone marrow stem cells (like GM-CSF)
Secreted by T-cells |
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IL-2
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Stimulates growth of helper and cytotoxic T cells
Secreted by Th1 cells Target of many immunosuppressants |
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Interferon-gamma
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Activates macrophages and Th1 cells
Suppresses Th2 cells. Antiviral and antitumor properties: cell mediated immunity Secreted by Th1 cells |
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IL-4
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Induces differentiation into Th2 cells
Promotes growth of B cells Enhances class switching to IgE and IgG-->increased IgE and IgG production secreted by Th2 cells |
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IL-5
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Promotes differentiation of B cells
Stimulates growth and differentiation of eosinophils Enhances class switching to IgA-->increased IgA "snot producing" |
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IL-10
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modulates inflammatory response
Inhibits actions of activated T cells, Th1, and macrophages Activates Th2 Secreted by Th2 cells and regulatory T cells |
