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16 Cards in this Set
- Front
- Back
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Il-1
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Secreted by macrophages
Causes acute inflammation Induces chemokine production to recruit leukocytes Activates endothelium to express adhesion molecules Pyrogen |
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Il-2
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Secreted by Th cells
Stimulates growth of helper and cytotoxic t cells |
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Il-3
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Secreted by activated T cells
Supports growth and differentation of bone marrow stem cells Similar fnc to GMCSF |
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Il-4
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Secreted by Th2 cells
Promotes growth of B cells Enhances class switching to IgE and IgG |
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Il-5
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Secreted by Th2 cells
Promotes differentiation of B cells Enhances class switching to IgA Stimulates production and activation of eosinophils |
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Il-6
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Secreted by Th cells and macrophges
Stimulates production of acute phase reactants and immunoglobulines |
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Il-8
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Secreted by macrophages
Major chemotactic factor for neutrophils |
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Il-10
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Secreted by regulatory T cells
Inhibits actions of activated T cells Inhibits formation of Th1 cells |
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Il-12
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Secreted by B cells and macrophages
Activates NK cells and Th1 cells |
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gamma interferon
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Secreted by Th1 cells to stimulate macrophages
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TNF
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Secreted by macrophages
Mediates septic shock Causes leukocyte recruitment, vascular leak |
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What cell surface proteins are on helper T cells
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CD4
TCR CD3 CD28 CD40L |
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What cell surface proteins are on cytoxic T cells
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CD8
TCR CD3 |
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What cell surface proteins are on B cells
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IgM
B7 (CD80, 86) CD19 CD20 CD21 CD40 MHCII |
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What cell surface proteins are on macrophages
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MHC II
B7 CD40 CD14 Receptors for Fc and C3b |
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What cell surface proteins are on NK cells
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Receptors fo MHC I
CD16 (binds Fc of IgG) CD56 |
