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17 Cards in this Set
- Front
- Back
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IL-1
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innate immunity cytokine, released from monocytes/macrophages/endothelial cells/ epithelial cells. Targets the vasculature (inflammation), hypothalamus (fever), liver (induction of acute phase proteins), immunoglobulin family of receptors
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IL-2
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adaptive immunity cytokine, released from T cells, role in T-cell proliferation; can promote AICD. NK cell activation and proliferation; B-cell proliferation
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IL-4
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adaptive immunity cytokine, Released from TH2 cells and mast cells, promotes TH2 differentiation and isotype switching to IgE
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IL-5
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Adaptive immunity cytokine, released from TH2 cells, contributes to eosinophil activation and generation
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IL-6
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Innate immunity cytokine, secreted from macrophagers and endothelial cells. Targets the liver (induces acute phase proteins), influences adaptive immunity (proliferation and antibody secretion of B cell lineage)
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IL-8
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chemokine released from many cell types that function as a chemoattractant and activator of neutrophils, chemokine family
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IL-10
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ligand for Class II cytokine family, released from activated CD4+ or CD8+ T cells and stimulates proliferation of B cells, thymocytes, and mast cells. Stimulates IgA synthesis when combined with TGF-B, antagonizes TH1 helper T cells
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IL-12
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Innate immunity cytokine released from macrophages and DCs - targets NK cells and influences adaptive immunity (promote TH1)
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IL-18
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Ligand for Ig family of receptors, released frmo DCs, promotes TH1 subset and induces IFN-g production of T cells and enhances NK cell cytotoxicity
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GM-CSF
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Growth factor for hematopoietic progenitor cells and differentiation factor for granulocytic and monocytic cell lineages
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IFN-a
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induces resistance to viruses and inhibits cell proliferation; regulates expression of class I MHC molecules on nucleated cells
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IFN-B
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Induces resistance to virus infection in targe4t cells, inhibits cell proliferation and regulates expression of class I MHC molecules
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IFN-g
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Affects activation, growth, and differntiation of T cells, B cells, and macrophages as well as NK cells; upregulates MHC expression on APCs; signature cytokine of TH1 differentiation; weak antiviral and antiproliferative properties
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TNF-a
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strong mediator of inflammatory and immune functions, known to regulate growth and differentiation of a wide variety of cell types; cytotoxic for many types of transformed cells; promotes angiogenesis, bone resorption, and thrombotic processes; suppresses lipogenetic metabolism
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TNF-B
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inhibits osteoclasts and keratinocyte growth, anti-angiogenic, and promotes fibroblasts proliferation; induces terminal differentiation of monocytes; stimulates neutrophil production of reactive oxygen species, increases phagocytosis, enhances adhesion
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MIP-1
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macrophage inflammatory protein, CCL4 - serves as a chemokine/attractant for monocytes and NK cells
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cD-25
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Alpha chain of the IL-2R, referred to as the T-cell activation antigen, marks mature T cells in a state of activation or Treg cells
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