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50 Cards in this Set
- Front
- Back
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Macrophages secrete
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IL-1
IL-6 IL-12 IL-23 TNF CSF IL-8 MCP-1 |
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Dendritic cell secretes
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IL-12
IL-23 |
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neutral killer cell
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IFN-GAMMA
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mast cell
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IL-4
IL-5 IL-15 IL-18 |
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Thp
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IL-2
IL-3 - hematopoeisis GM-CSF - hematopiesis |
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Tho
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IL-2
IL-4 IFN-G IL-3 GM-CSF |
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Th1
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IL-2
IFN-G TNF IL-3 GM-CSF |
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Th2
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IL-4
IL-5 IL-6 IL-10 TGF-b |
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Th17
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IL-17A
IL-17F IL-21 IL-22 |
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Endothelial
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IL-8 (CXCL8)
MCP-1(CCL2) |
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Epithelial
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CCL11
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Fibroblast
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CCL11
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Bone marrow cells
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GM-CSF (also T cells)
M-CSF G-CSF All CSFs are also secreted by Macrophages |
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Enhances marcophage to secrete cytokines and chemokines
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IL-1
TNF |
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Activate endothelial cells make VCAM-1, ICAM-1, E-selectin, enhance expression ICAM-2 (always on cell surface), secreter IL-8 and MCP-1
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IL-1
TNF |
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Hypothalamus --> fever and shock
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IL-1
TNF |
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Enhances NADPH oxidase
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TNF
IFN-g |
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induces iNOS
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TNF (with second signal)
IFN-g |
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Growth factor for T cells
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IL-2
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Enhances NK cytotoxicity
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IL-2
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pCTL -> CTL
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IL-2
IFN-g |
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Inhibitory Th17 cells
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IL-2
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Hematopoieisis: pluripotent stem cell ---> myeloid and lymphoid progenitor
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IL-3
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Isotype switching to IgE
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IL-4
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Down regulation of Th1
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IL-4
Only IL-4 down regulates Th1, while IL-4,10, TGF-b down iNOs |
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Down regulates Th1 cytokines production
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IL-4
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Differentiation to esosinophil
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IL-5
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Chemotactic for eosinophil
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IL-5 (from mast cell goes to marrow, release eosinophil)
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Activation of eosinophil
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IL-5
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Shift Tho ---> Th2
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IL-4
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Stimulate secretion of C-Reactive protein from hepatocyte
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IL-6
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Tho ----> Th17
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TGF-b with IL-6
TGF-b with IL-21 (while Th17 appears already) only TGF-b : Tho ---> a/iTreg |
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Bone marrow and thymus ---> T cells
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IL-7
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Chemokines for neutrophil (not NK)
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IL-8 (from macrophage and endothelial)
IL-17A (from Th17) |
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Down reg of IL-12 secreted by dendritic cells ---> less IFN-g ---> Down reg of Th1 cells
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IL-10
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Tho ----> Tr1
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IL-10 and IFN-a
(not IFN-gamma) |
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Activate NK cells to secrete IFN-g
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IL-12 (from dendritic)
IL-15 (from mast cells) IL-18 (from mast cells) |
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Down regulates production of Th2 cytokines
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IFN-g
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CRITICAL for Tho -----> Th1
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IFN-g
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Enhances expression of MHC-1
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IFN-g
IFN a/b |
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Enhances expression of MHC II on APC
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IFN-g
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Trigger virus infected cell releases 2,5 oligoadenylase synthase
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IFN-a/b
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Inhibition of T cells proliferation
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IFN-a/b
While IL-2 : growth factor of T cells and inhibits Th17 |
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Tho -----> a/i Treg
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TGF-b
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Induces expression proinflammatory cytokines and chemokines from wide range of cells (IL-6, IL-8, GM-CSF, G-CSF, metalloproteinase)
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IL-17A
IL-17F |
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Autoimmune disorder if Th17 cells specifics for self-antigen
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IL-17A
IL-17F |
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Amplification of Th17
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IL-21
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Proinflammatory
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IL-22 (Th17)
IL-6 IL-8 GM-CSF |
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Stabilization of Th17
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IL-23
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Nothing
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Nothing
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