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9 Cards in this Set
- Front
- Back
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Most common CF mutation? |
F508 delta |
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Which mutation does the drug Ivacaftor work for? |
G551D mutation found in 4-5% of CF population £182624/yr - only continued if swear chloride test shows reduction of 30% or FEV1 improves but more than 5% |
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How does dornase alpha work? |
Hydrolyses DNA in sputum and greatly reduces the viscoelasticity of cystic fibrosis sputum |
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What is incidence of cystic fibrosis in the uk? |
1 in 2500 |
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Which CF mutation patients is drug Ivacaftor indicated? |
G551D Taken PO BD |
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Which CF mutation patients is drug Ivacaftor indicated? |
G551D Taken PO BD |
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What does CTFR stand for? |
Cystic Fibrosis Transmembrane Conductance Regulator |
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What is the role of CTFR |
A cAMP dependent chloride ion channel in the membrane of luminal surfaces. Allows passage of chloride and sodium ions out of cell |
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What is the CRB 65 score for mortality risk assessment? |
Confusion Respiratory rate (raised - 30 breaths per min or more) Blood pressure (low - diastolic 60mmHg or less, or systolic <90mmHg) 65 patients aged 65 or more |
