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11 Cards in this Set
- Front
- Back
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CYP1 family inducers
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cigarette smoke
omeproazole |
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CYP2A, B, C inducers
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anticonvulsants:
barbiturates phenytoin carbamazepine |
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CYP2D inducers
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noninducable
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CYP2E inducers
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alcohol (ethanol)
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CYP3A inducers
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St John's Wort
anticonvulsants (barbs, phenytoin, carbamazepine) dexamethasone macrolides azole antifungals HIV protease inhibitors |
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Common broad classes of CYP inhibitors? (per lecture)
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sp2 hybridized nitrogens: Fluvoxamine
drugs w/amine + large hydrophobic groups (macrolides, fluoxetine) grapefruit juice |
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Example Substrate of CYP2A6?
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Nicotine
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Example substrate of CYP2B6?
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Bupropion
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Example substrate of CYP3A5?
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midazolam, cyclosporine, calcium channel blockers
**only 25% of caucasion pts have this enzyme |
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Example substrates of CYP2C9, 19?
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mephenytoin/phenytoin
warfarin clopidogrel omeprazole |
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Why is there a DDI w/digoxin + abx?
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Digoxin degraded by gut bacterial reductases; abx wipe out gut flora --> digox accumulates to dangerous levels
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