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9 Cards in this Set

  • Front
  • Back
Object Drugs (need acid for absorption)
Ketoconazole
Itraconazole (caps, not oral solution)
Dapsone
EC Tablets
Increased pH of Gastric Fluid
H2 receptor antagonists
Antacids
DDI
Proton Pump Inhibitors
Age
Increased pH of Gastric Fluid Management
Choose alternative agent
Fluconazole, voriconazole
Administer drug with acidic drink and separate doses
Use liquid formulation of itraconazole
Object Drugs
Warfarin
PHT
Valproic Acid
Amiodarone
Chloral hydrate
Valproic Acid
Salicylates
Nephrotoxic drugs may ↓ elimination
Aminoglycosides and amphotericin B
Increased/decreased reabsorption
Lithium and thiazides
Lithium and caffeine, theophylline
Alteration in urine pH may trap weak organic acids and bases
NaHCO3 and acetazolamide alkalinize distal tubule, cause ion trapping of ASA and ↑ excretion
May be used in ASA overdose
Drugs compete for tubular secretion
Penicillins/cephalosporins
Probenecid
Aspirin
Methotrexate
Dofetilide (Tikosyn) is eliminated via tubular secretion and competes with others

CI
Cimetidine
Verapamil
Megestrol
Ketoconazole
Prochlorperazine
Trimethoprim (alone or with sulfamethoxazole)
HCTZ (alone or with triamterene)