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92 Cards in this Set
- Front
- Back
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Cigarettes
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1a2 inducers
2e1 inducer |
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charred food
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1a2 inducers
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modafinil
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1a2 INDUCER
2c9 INHIBITOR 2c19 INHIBITOR 3a4 INDUCER 3a4 substrate |
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omeprazole
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1a2 inducer
2c19 INHIBITOR 2c19 SUBSTRATE 3a4 inhibitor |
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rifampin
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(EVERYTHING BUT 2e1??)
Induces 1a2 2c9 2c19 2d6 3a4 p glycoprotein |
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Dioxin
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1a2 inducer
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brussel sprouts
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1a2 inducer
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amiodarone
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(EVERYTHING BUT 2E1??)
1a2 inhibitor 2c9 inhibitor 2c19 inhibitor 2d6 inhibitor 3a4 inhibitor p-glycoprotein inhibitor |
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cimetidine
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1a2 inhibitor
2c9 inhibitor 2d6 inhibitor 3a4 inhibitor |
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clarithromycin
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1a2 inhibitor
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erythromycin
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1a2 inhibitor
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fluvoxamine
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1a2 INHIBITOR
2c19 inhibitor |
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grapefruit juice
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1a2 inhibitor
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quinolones
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1a2 inhibitor
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caffeine
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1a2 substrate
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carvedilol
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1a2 substrate
2c19 substrate 2e1 substrate |
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clozapine
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1a2 substrate
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theophylline
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1a2 substrate
2e1 substrate 3a4 substrate |
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r-warfarin
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1a2 substrate
2c19 substrate 3a4 substrate |
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apap
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1a2 substrate
2e1 substrate 2e1 TOXICATION 3a4 toxication |
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haloperidol
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1a2 substrate
2d6 inhibitor 2d6 substrate |
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dichloromethane
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1a2 toxication
2c9 toxication 2e1 toxication |
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ethylene dichloride
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1a2 toxication
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benzo[a] pyrene
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1a2 toxication
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fluconazole
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2c9 inhibitor
2c19 inhibitor 3a4 inhibitor |
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INH
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2c9 inhibitor
2c19 inhibitor 2e1 INDUCER |
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Metronidazole
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2c9 inhibitor
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Paroxetine
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2c9 inhibitor
2c19 inhibitor |
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sertraline
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2c9 inhibitor
2d6 inhibitor |
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ethylene dichloride
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2c9 toxication
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vinyl chloride
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2c9 toxication
2c19 toxication 2e1 toxication |
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NSAID
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2c9 substrate
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S-warfarin
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2c9 substrate
Most active isomer of warfarin! |
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sulfonylurea
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2c9 substrate
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phenytoin
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2c9 substrate
2c19 substrate 2e1 Inducer 3a4 inducer |
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ARB
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2c9 substrate
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Clozapine
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2c9 substrate
2c19 substrate 2e1 substrate |
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Lovastatin
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2c9 substrate
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carbamazepine
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2c19 inducer
3a4 inducer |
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prednisone
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2c19 inducer
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Efavirenz
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2c19 inhibitor
3a4 inducer |
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Felbamate
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2c19 inhibitor
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Ketoconazole
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2c19 inhibitor
3a4 inhibitor P-glycoprotein inhibitor |
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Ritonavir
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2c19 inhibitor
p glycoprotein inhibitor 2d6 inhibitor |
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Dexamethasone
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2d6 inducer
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Bupropion
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2d6 INHIBITOR
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Citalopram
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2d6 inhibitor
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chloroquine
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2d6 inhibitor
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desipramine
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2d6 inhibitor
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fluoxetine
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2d6 inhibitor
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h1 antagonists
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2d6 inhibitor
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methadone
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2d6 inhibitor
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quinidine
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2d6 inhibitor
p glycoprotein inhibitor |
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yohimbine
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2d6 inhibitor
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b-blocker
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2d6 substrate
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codeine
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2d6 SUBSTRATE
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oxycodone
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2d6 SUBSTRATE
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TCAs
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2d6 substrate
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ethanol
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2e1 Inducer
2e1 inhibitor (chronic) |
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Fomepizole
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2e1 inducer
2e1 inhibitor |
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Phenobarbital
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2e1 inducer
3a4 inducer |
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disulfiram
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2e1 inhibitor
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Ifosphamide
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2e1 toxication
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acrylonitrile
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2e1 toxication
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CCl4
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2e1 toxication
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aniline
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2e1 toxication
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benzene
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2e1 toxication
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Anesthetics
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2e1 substrate
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glucocorticoids
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3a4 inducer
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St Johns Wort
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3a4 inducer
p glycoprotein inducer |
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Clarithromycin
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3a4 inhibitor
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diltiazem
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3a4 inhibitor
p glycoprotein substrate |
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cyclosporine
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3a4 inhibitor
p glycoprotein substrate |
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erythromycin
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3a4 inhibitor
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HIV alpha viral
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3a4 inhibitor
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verapamil
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3a4 inhibitor
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aflatoxin
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3a4 toxication
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Benzos
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3a4 substrate
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dapsone
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3a4 substrate
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Ca2+ blockers
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3a4 substrate
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Statins
|
3a4 substrate
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Macrolides (not azith)
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3ar substrate
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ziprasidone
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3a4 substrate
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loperamide
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p-glycoprotein substrate
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lovastatin
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p-glycoprotein substrate
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tamoxifen
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p-glycoprotein inhibitor
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p-glycoprotein inducers
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rifampin
st johns wort |
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p-glycoprotein inhibitors
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amiodarone
cyclosporine ketoconazole quinidine ritonavir tamoxifen verapamil |
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CYP 2d6 facts
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Greatest degree of polymorhisms
25% drugs 50% antipsychotics 10% W, 8% AA poor metabolizers Ethiopian ultra-rapid metabolizer |
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CYP 3a4 facts
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most abundant in liver and intestine
50-60% all pharmaceuticals |
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2c19 facts
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absent in 20% asians
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cyp450 linked with CA
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1a2
2e1 |
