Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
CYP 2C19 polymorphism
|
Oriental 20% PM
Black 18% PM White 3% PM Citalopram, clomipramine, imipramine, diazepam, propranolol |
|
|
CYP 2D6 polymorphism
|
White 8% PM
Black 4% PM Oriental 1% PM haloperidal, perphenazine, risperidone, thioridazine, beta blockers, opiates, fluoxetine, paroxetine, TCAs, venlafaxine |
|
|
CYP 1A2
|
substrates: amiptryptiline, imipramine, clomipramine, clozapine, olanzapine
Inhib: fluvoxamine, verapamil Ind: tobacco |
|
|
CYP 2C9
|
phenytoin, warfarin, NSAIDs
Inhib: Valproic acid |
|
|
CYP 2C19
|
amitriptyline, citalopram, diazepam, phenytoin, impramine, clomipramine, moclobemide
Inhib: moclobemide, fluoxetine, fluvoxamine Ind: |
|
|
CYP 2D6
|
Most active in psychoactive drugs: beta blockers, all TCAs, most SSRIs, venlafaxine, many antipsychotics
Inhib: citalopram, fluoxetine, buproprion, duloxetine, fluvoxamine, |
|
|
CYP 3A4
|
Most prevalent for all drugs: benzodiazepines, amitriiptyline, impramine, clomipramine, citalopram, sertraline, fluoxetine, buspirone, venlafaxine, haloperidol, atypicals
inhib: nefazodone, antifungals, grapefruit juice |
