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7 Cards in this Set
- Front
- Back
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What are four phagocytic cell deficiencies?
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Chronic granulomatous disease (CGD)
Leukocyte adhesion deficiency (LAD) Chediak-Higashi disease Job's syndrome |
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What are six B-cell deficiencies?
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X-linked (Bruton's) agammaglobulinemia
Selective IgA deficiency Selective IgG2 and IgG4 deficiency Immunodeficiency with hyper-IgM Common Variable immunodeficiency Transient hypogammaglobulinemia of infancy |
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What are five T-cell deficiencies?
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Severe combined immunodeficiency (SCID)
Congenital thymic aplasia (DiGeorge syndrome) Hereditary ataxia telangiectasia Wiscott-Aldrich syndrome AIDS |
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What are the causes and symptoms of Chronic Granulomatous Disease?
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Cause: due to peroxisome deficiency, neutrophils engulf but cannot destroy microorganisms.
Symptoms: granulomas, pneumonia, abscesses |
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What are the causes and symptoms of Leukocyte Adhesion Deficiency?
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Cause: defective CD18, the β chain of LFA-1 and CR3
Symptoms: insufficient pus formation, severe bacterial infections of mouth and GI tract, blood neutrophil count elevated |
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What are the causes and symptoms of Chediak-Higashi disease?
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Cause: defective phagocytosis due to defects in microtubules and lysosomes
Symptoms: albinism, recurrent pyogenic Staph and Strep infections |
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What are the causes and symptoms of Job's syndrome?
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Cause: neutrophils don't respond to chemotactic stimuli
Symptoms: recurrent cold Staph abscesses, elevated IgE, eczema, otitis media |
